6
Participants
Start Date
August 6, 2020
Primary Completion Date
July 11, 2022
Study Completion Date
September 28, 2022
Neuronavigation-guided single-element focused ultrasound transducer
Non-invasive focused ultrasound-induced blood-brain barrier opening will be attempted using a single-element transducer, guided with a neuronavigation system.
Definity
Definity microbubbles (10 μl/kg) will be used in conjunction with the ultrasound transducer to temporarily open the blood brain barrier.
Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents
MRI scans will be completed at baseline and immediately after the focused ultrasound treatment to confirm BBB opening and safety. A follow-up MRI will be performed three days after treatment to confirm BBB closure, only in the case of successful BBB opening.
Positron Emission Tomography (PET)
A follow-up PET scan will be performed three days after treatment to determine amyloid plaque load.
Amyvid
To be used during the PET scan to determine uptake of Amyvid within the treated area.
Columbia University Irving Medical Center/NYPH, New York
National Institute on Aging (NIA)
NIH
Columbia University
OTHER