Antidepressant Trial With P2X7 Antagonist JNJ-54175446

PHASE2UnknownINTERVENTIONAL
Enrollment

142

Participants

Timeline

Start Date

September 12, 2019

Primary Completion Date

December 31, 2023

Study Completion Date

June 30, 2024

Conditions
Depressive Disorder, MajorInflammation
Interventions
DRUG

Active JNJ-54175446

JNJ-54175446 is a novel, potent, selective, and brain-penetrant antagonist of the adenosine triphosphate (ATP)-gated P2X7 channel.

DRUG

Placebo

Matching placebo containing the same excipients

Trial Locations (5)

CB2 0QQ

Addenbroooke's Hospital, Cambridge

CF24 4HQ

Cardiff University Brain Research Imaging Centre, Cardiff

G3 8SW

Queen Elizabeth University Hospital, Glasgow

SE5 9RT

The Maurice Wohl Clinical Neuroscience Institute, London

OX3 7JX

Warneford Hospital, Oxford

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Janssen Pharmaceuticals

INDUSTRY

lead

CCTU-Core

OTHER