277
Participants
Start Date
August 27, 2015
Primary Completion Date
June 10, 2024
Study Completion Date
June 10, 2024
blood sampling for research purpose
blood sampling for research purpose (about 30ml) taken by venepuncture or from intravenous catheters if already in place
clinical data collection
clinical data collection in order to document the stage of disease, the presence of infection and existing complications of cirrhosis (ascites, hepatic encephalopathy, renal dysfunction, pulmonary dysfunction) and concomitant disease. These data will be collected for clinical reasons as highly important in the context of patients with cirrhosis and possible decompensation or liver failure and will therefore not require additional time
Health-related Questionnaires
Health-related Questionnaires (Questionnaire\_CLD) regarding sleep characteristics (Pittsburgh sleep Quality index, PSQI), daytime sleepiness (Epworth sleepiness scale, ESS), anxiety and depression (Hospital Anxiety and Depression Scale, HADS) and quality of life (EQ-5D-5L)
Sampling other biological materials (e.g. liver biopsies, liver resections, ascites, urine, gut biopsies)
Other biological material (e.g. liver biopsies, liver resections, ascites, urine, gut biopsies) will only be investigated if sampled for clinical reasons and if excessive material is available that is not needed for clinical purpose.
University Hospital Basel, Hepatology Department and Laboratory, Basel
Cantonal Hospital St. Gallen, Sankt Gallen
King's College Hospital, Institute of Liver studies, London
St. Mary's Hospital, Imperial College London, Section of Hepatology, London
Swiss National Science Foundation
OTHER
University Hospital, Basel, Switzerland
OTHER