Single Fraction Stereotactic Radiosurgery Compared with Fractionated Stereotactic Radiosurgery in Treating Patients with Resected Metastatic Brain Disease

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

242

Participants

Timeline

Start Date

November 19, 2019

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2028

Conditions
Metastatic Malignant Neoplasm in the Brain
Interventions
RADIATION

Single Fraction Stereotactic Radiosurgery

Undergo SSRS

RADIATION

Fractionated Stereotactic Radiosurgery

Undergo FSRS

PROCEDURE

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (232)

10011

Mount Sinai Chelsea, New York

10019

Mount Sinai West, New York

10029

Mount Sinai Hospital, New York

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

11794

Stony Brook University Medical Center, Stony Brook

12801

Glens Falls Hospital, Glens Falls

13210

State University of New York Upstate Medical University, Syracuse

13421

Upstate Cancer Center Radiation Oncology at Oneida, Oneida

14642

University of Rochester, Rochester

18512

Northeast Radiation Oncology Center, Dunmore

18840

Guthrie Medical Group PC-Robert Packer Hospital, Sayre

18925

Fox Chase Cancer Center Buckingham, Furlong

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19713

Helen F Graham Cancer Center, Newark

19971

Beebe Health Campus, Rehoboth Beach

21237

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore

22031

Inova Schar Cancer Institute, Fairfax

22908

University of Virginia Cancer Center, Charlottesville

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

27103

Novant Health Forsyth Medical Center, Winston-Salem

28204

Novant Health Presbyterian Medical Center, Charlotte

29169

Lexington Medical Center, West Columbia

29607

Saint Francis Cancer Center, Greenville

29651

Gibbs Cancer Center-Pelham, Greer

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33486

Boca Raton Regional Hospital, Boca Raton

33607

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

33612

Moffitt Cancer Center, Tampa

33756

Morton Plant Hospital, Clearwater

35233

University of Alabama at Birmingham Cancer Center, Birmingham

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

39216

University of Mississippi Medical Center, Jackson

40536

University of Kentucky/Markey Cancer Center, Lexington

43210

Ohio State University Comprehensive Cancer Center, Columbus

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

48043

McLaren Cancer Institute-Macomb, Mount Clemens

48060

McLaren-Port Huron, Port Huron

48106

Saint Joseph Mercy Hospital, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

Saint Joseph Mercy Brighton, Brighton

48118

Saint Joseph Mercy Chelsea, Chelsea

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Saint Joseph Mercy Canton, Canton

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48374

Ascension Providence Hospitals - Novi, Novi

48532

McLaren Cancer Institute-Flint, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48706

McLaren Cancer Institute-Bay City, Bay City

48910

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing

49503

Spectrum Health at Butterworth Campus, Grand Rapids

49770

McLaren Cancer Institute-Northern Michigan, Petoskey

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53045

Ascension Southeast Wisconsin Hospital - Elmbrook Campus, Brookfield

53132

Ascension Saint Francis - Reiman Cancer Center, Franklin

53188

UW Cancer Center at ProHealth Care, Waukesha

53211

Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

53405

Ascension All Saints Hospital, Racine

53792

University of Wisconsin Carbone Cancer Center, Madison

54017

Cancer Center of Western Wisconsin, New Richmond

54311

Aurora BayCare Medical Center, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54601

Gundersen Lutheran Medical Center, La Crosse

54806

Northwest Wisconsin Cancer Center, Ashland

55008

Cambridge Medical Center, Cambridge

55082

Lakeview Hospital, Stillwater

55092

Fairview Lakes Medical Center, Wyoming

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55362

Monticello Cancer Center, Monticello

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55371

Fairview Northland Medical Center, Princeton

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55805

Miller-Dwan Hospital, Duluth

55905

Mayo Clinic in Rochester, Rochester

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

Sanford Joe Lueken Cancer Center, Bemidji

58122

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Deaconess Hospital, Bozeman

59804

Community Medical Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60611

Northwestern University, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

62226

Southwest Illinois Health Services LLP, Swansea

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63110

Washington University School of Medicine, St Louis

63127

Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63628

Parkland Health Center-Bonne Terre, Bonne Terre

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65109

Capital Region Southwest Campus, Jefferson City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

70809

Mary Bird Perkins Cancer Center, Baton Rouge

70817

Woman's Hospital, Baton Rouge

72401

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

72903

Mercy Hospital Fort Smith, Fort Smith

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

M D Anderson Cancer Center, Houston

Memorial Hermann Texas Medical Center, Houston

80045

University of Colorado Hospital, Aurora

80909

UCHealth Memorial Hospital Central, Colorado Springs

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83617

Walter Knox Memorial Hospital, Emmett

83642

Idaho Urologic Institute-Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85006

Banner-University Medical Center Phoenix, Phoenix

85054

Mayo Clinic Hospital in Arizona, Phoenix

85234

Banner MD Anderson Cancer Center, Gilbert

85259

Mayo Clinic in Arizona, Scottsdale

85306

Banner Thunderbird Medical Center, Glandale

85719

University of Arizona Cancer Center-North Campus, Tucson

87102

University of New Mexico Cancer Center, Albuquerque

90033

Los Angeles County-USC Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

94597

Epic Care Cyberknife Center, Walnut Creek

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97814

Saint Alphonsus Medical Center-Baker City, Baker City

97914

Saint Alphonsus Medical Center-Ontario, Ontario

99504

Anchorage Radiation Therapy Center, Anchorage

06520

Yale University, New Haven

32224-9980

Mayo Clinic in Florida, Jacksonville

04074

Maine Medical Center- Scarborough Campus, Scarborough

07039

Saint Barnabas Medical Center, Livingston

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

08755

Community Medical Center, Toms River

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

H2X 3E4

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

H3H 2R9

The Research Institute of the McGill University Health Centre (MUHC), Montreal

H3T 1E2

Jewish General Hospital, Montreal

G1R 2J6

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER