Intraoperative Dexmedetomidine and Long-term Outcomes in Elderly After Major Surgery

A loading dose of dexmedetomidine (0.6 μg/kg) was administered during a 10-minute period before anaesthesia induction, followed by a continuous infusion at a rate of 0.5 μg/kg/hr till 1 hour before the end of surgery.

Volume-matched normal saline was administered in the same rate for the same duration as in the intervention group.