Trial to Compare Efficacy and Safety of Chemotherapy/Quizartinib vs Chemotherapy/Placebo in Adults FMS-like Tyrosine Kinase 3 (FLT3) Wild-type Acute Myeloid Leukemia (AML)

PHASE2CompletedINTERVENTIONAL
Enrollment

273

Participants

Timeline

Start Date

September 5, 2019

Primary Completion Date

October 3, 2024

Study Completion Date

January 24, 2025

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Quizartinib

"Induction: oral quizartinib (dose defined in safety run-in phase) 14 days (8-21) (dose will be halved with strong CYP3A inhibitor), up to 2 cycles of 35 days.~Consolidation: oral quizartinib (dose defined in safety run-in phase) 14 days (6-19) (dose will be halved with strong CYP3A inhibitor), up to 4 cycles of 35 days.~Maintenance: oral quizartinib 60mg/day (dose will be halved with strong CYP3A inhibitor), up to 12 cycles of 28 days."

DRUG

Placebo oral tablet

"Induction: oral placebo (dose defined in safety run-in phase) 14 days (8-21) (dose will be halved with strong CYP3A inhibitor), up to 2 cycles of 35 days.~Consolidation: oral placebo (dose defined in safety run-in phase) 14 days (6-19) (dose will be halved with strong CYP3A inhibitor), up to 4 cycles of 35 days.~Maintenance: oral placebo 60mg/day (dose will be halved with strong CYP3A inhibitor), up to 12 cycles of 28 days."

DRUG

Cytarabine

"Induction: Cytarabine continuous IV infusion, 200 mg/m2 (days 1-7), up to 2 cycles of 35 days.~Consolidation: Cytarabine IV infusion, 1,5-3 g/m2 (days 1, 3, 5), up to 4 cycles of 35 days."

DRUG

Idarubicin

Induction: Idarubicin IV infusion 12 mg/m2 (days 1-3), up to 2 cycles of 35 days.

Trial Locations (44)

10003

Hospital San Pedro de Alcántara, Cáceres

12004

Hospital General Univesitario de Castellón, Castellon

14004

Complejo Hospitalario Regional Reina Sofía, Córdoba

15706

Complejo Hospitalario Universitario de A Coruña, Santiago de Compostela

Complejo Hospitalario Universitario de Santiago, Santiago de Compostela

21005

Hospital Juan Ramón Jiménez, Huelva

23007

Complejo Hospitalario de Jaén, Jaén

27003

Complejo Hospitalario Lucus Augusti, Lugo

28040

Fundación Jiménez Díaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28223

Hospital Universitario Quirón Salud Madrid, Pozuelo de Alarcón

29010

Hospital Regional Universitario Málaga, Málaga

Hospital Universitario Virgen de la Victoria, Málaga

30200

Hospital General Universitario Santa Lucía, Cartagena

31008

Complejo Universitario de Navarra, Pamplona

33006

Hospital Universitario Central de Asturias, Oviedo

35020

Complejo Hospitalario Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria

36071

Complejo Hospitalario de Pontevedra, Pontevedra

36312

Complejo Hospitalario Universitario de Vigo, Vigo

37007

Hospital Universitario de Salamanca, Salamanca

38320

Hospital Universitario de Canarias, San Cristóbal de La Laguna

39008

Hospital Universitario Marques de Valdecilla, Santander

41013

Complejo Hospitalario Regional Virgen del Rocío, Seville

45004

Complejo Hospitalario de Toledo, Toledo

46010

Hospital Clínico Universitario Valencia, Valencia

46017

Hospital Universitario Dr. Peset Aleixandre, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

47003

Hospital Clínico Universitario de Valladolid, Valladolid

48013

Hospital Universitario de Basurto, Bilbao

48960

Hospital Universitario de Galdakao, Galdakao

50009

Hospital Clínico Universitario Lozano Blesa, Zaragoza

Hospital Universitario Miguel Servet, Zaragoza

08916

Hospital Universitari Germans Trias i Pujol, Badalona

02006

Complejo Hospitalario de Albacete, Albacete

03010

Hospital General Universitario de Alicante, Alicante

08035

Hospital Universitari Vall Hebron, Barcelona

09006

Hospital Universitario de Burgos, Burgos

Unknown

Hospital Puerta del Mar, Cadiz

Hospital Clínico San Carlos, Madrid

Hospital La Paz, Madrid

Hospital Ramón y Cajal, Madrid

Hospital Virgen de la Arrixaca, Murcia

Hospital Nuestra Señora del Prado, Talavera de la Reina

01009

Hospital Txagorritxu, Vitoria-Gasteiz

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Dynamic Science S.L.

INDUSTRY

collaborator

Daiichi Sankyo

INDUSTRY

lead

PETHEMA Foundation

OTHER