Looking at Cognitive and Brain Changes in People With Lymphoma Receiving CAR-T Therapy

RecruitingOBSERVATIONAL
Enrollment

120

Participants

Timeline

Start Date

September 25, 2019

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2026

Conditions
Lymphoma Receiving CAR-T Therapy
Interventions
BEHAVIORAL

neurocognitive evaluations

The test battery consists of validated and reliable measures of attention, executive functions and memory.

DIAGNOSTIC_TEST

brain MRIs

Patients will undergo baseline and follow-up research MRIs in the same scanner at MSKCC (3 Tesla scanner (GE, Discovery 750W, USA) with a GEM HNU 24-channel head coil) (total scan duration=15 minutes).

OTHER

Blood samples

Blood samples will be collected at each time point (Day -1, day 0, day 1, day 3, day 5, day 7, day 10, day of neurotoxicity onset, and 3-4 months post- CART).

Trial Locations (1)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

All Listed Sponsors
lead

Memorial Sloan Kettering Cancer Center

OTHER