Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation

CompletedOBSERVATIONAL
Enrollment

15

Participants

Timeline

Start Date

February 10, 2020

Primary Completion Date

December 31, 2021

Study Completion Date

December 31, 2021

Conditions
Diaphragm InjuryLung Transplant; Complications, MechanicalRespiratory FailureMechanical Ventilation Complication
Interventions
DIAGNOSTIC_TEST

Ultrasound

Sonographic measurements (diaphragm, abdominal muscle, and quadriceps thickness) will be acquired when listed for lung transplantation. Sonographic measurements will be recorded on a daily basis for up to 1 week after transplantation (while the patient remains intubated).

DIAGNOSTIC_TEST

Respiratory function measurements

Maximal expiratory pressure (MEP) and maximal inspiratory pressure (MIP) will be acquired after listing for lung transplantation. After transplant, MIP will be recorded once patients are eligible for a trial of spontaneous breathing and weekly thereafter. MEP will also be recorded at ICU discharge.

Trial Locations (1)

Unknown

Toronto General Hospital, Toronto

All Listed Sponsors
lead

University Health Network, Toronto

OTHER

NCT04103996 - Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation | Biotech Hunter | Biotech Hunter