A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

668

Participants

Timeline

Start Date

December 31, 2019

Primary Completion Date

October 21, 2022

Study Completion Date

July 16, 2027

Conditions
Carcinoma, Hepatocellular
Interventions
DRUG

Atezolizumab

Atezolizumab 1200 mg will be administered by IV infusion on Day 1 of each 21-day cycle.

DRUG

Bevacizumab

Bevacizumab will be administered by IV infusion at a dose of 15 mg/kg on Day 1 of each 21-day cycle.

Trial Locations (134)

0

Queen Mary Hospital, Hong Kong

100

National Taiwan Uni Hospital, Taipei

112

Taipei Veterans General Hospital, Taipei

333

Chang Gung Medical Foundation - Linkou, Taoyuan District

500

Changhua Christian Hospital, Chang-hua

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1023

Auckland City Hospital, Auckland

1090

Medizinische Universität Wien, Vienna

2010

St Vincent's Hospital Sydney, Darlinghurst

2820

Imeldaziekenhuis, Bonheiden

6351

Samsung Medical Center, Seoul

8036

Lkh-Univ. Klinikum Graz, Graz

8800

AZ Delta (Campus Rumbeke), Roeselare

9020

Klinikum Klagenfurt am Wörtersee, Klagenfurt

10032

Columbia University Medical Center, New York

10103

Clinica CIMCA, San José

10210

Chulabhorn Hospital, Lak Si

10400

Rajavithi Hospital, Bangkok

10700

Siriraj Hospital, Bangkok

12345

Anhui Province Cancer Hospital, Hefei

13285

Fondation Hopital Saint Joseph, Marseille

13496

CHA Bundang Medical Center, Gyeonggi-do

13620

Seoul National University Bundang Hospital, Gyeonggi-do

15038

Instituto Nacional de Enfermedades Neoplasicas, Lima

15088

Clínica San Gabriel, Lima

16499

Ajou University Medical Center, Gyeonggi-do

19107

Thomas Jefferson University, Philadelphia

20122

Ospedale Maggiore Policlinico, Milan

20142

Asst Santi Paolo E Carlo, Milan

21202

Mercy Medical Center, Baltimore

25030

Hopital Jean Minoz, Besançon

28007

Hospital General Universitario Gregorio Marañon, Madrid

28222

Hospital Universitario Puerta de Hierro, Majadahonda

31059

CHU de Toulouse - Hôpital Rangueil, Toulouse

33604

CHU Bordeaux - Hôpital Haut-Lévêque, Pessac

35033

Hopital de Pontchaillou, Rennes

38700

Hôpital Albert Michallon, La Tronche

41944

Kyungpook National University Hospital, Daegu

43100

Ospedale Regionale Di Parma, Parma

44033

Ulsan University Hosiptal, Ulsan

48202

Henry Ford Health System, Detroit

49241

Pusan National University Hospital, Busan

51092

Hopital Robert Debre, Reims

53127

Universitätsklinikum Bonn, Medizinische Klinik und Poliklinik I., Bonn

54511

Hopitaux de Brabois - Gastro-Entereologie, Vandœuvre-lès-Nancy

56100

Azlenda Ospendaliero-Universitaria Pisana, Pisa

57000

Chiang Rai Prachanukroh Hospital, Chiang Rai

60590

Klinik Johann Wolfgang von Goethe Uni, Frankfurt am Main

64460

Filios Alta Medicina, Monterrey

68000

Oaxaca Site Management Organization, Oaxaca City

75390

The University of Texas Southwestern Medical Center at Dallas, Dallas

77030

MD Anderson Cancer Center, Houston

89081

Universitätsklinikum Ulm, Ulm

90027

Kaiser Permanente Los Angeles, Los Angeles

93009

Hôpital Avicenne - Groupement Hospitalier Universitaire Paris Seine St Denis, Bobigny

93053

Klinikum der Uni Regensburg, Regensburg

98104

Swedish Cancer Inst., Seattle

100142

Beijing Cancer Hospital, Beijing

100730

Peking Union Medical College Hospital, Beijing

105229

"Group of companies Medci", Moskva

110001

The First Affiliated Hospital of China Medical University, Shenyang

110004

Shengjing Hospital of China Medical University, Shenyang

116027

The Second Affiliated Hospital of Dalian Medical University, Dalian

119991

First Moscow State Medical University n.a. I.M. Sechenov, Moscow

130021

The First Hospital of Jilin University, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

168583

National Cancer Centre, Singapore

197758

Russian Scientific Center of Radiology and Surgical Technologies, Pesochny

200032

Fudan University Shanghai Cancer Center, Shanghai

200040

Huashan Hospital Affiliated to Fudan University, Shanghai

200127

Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai

210002

The 81st Hospital of P.L.A., Nanjing

210009

Zhongda Hospital Affiliated to Southeast University, Nanjing

210029

Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing

230001

Anhui Provincial Hospital, Anhui

230601

The Second Affiliated Hospital of Anhui Medical University, Hefei

233004

Affiliated Hospital of Bengbu Medical College, Bengbu

250117

Shandong Cancer Hospital, Jinan

300060

Tianjin Cancer Hospital, Tianjin

308433

Tan Tock Seng Hospital, Singapore

310022

Zhejiang Cancer Hospital, Hangzhou

350014

Fujian Cancer Hospital, Fuzhou

350025

Mengchao Hepatobiliary Hospital Of Fujian Medical University, Fuzhou

400042

Daping Hospital of Third Military Medical University, Chongqing

430022

Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430060

Renmin Hospital of Wuhan University, Wuhan

430071

Zhongnan Hospital of Wuhan University, Wuhan

510000

Cancer Center of Guangzhou Medical University, Guangzhou

510060

Sun Yet-sen University Cancer Center, Guangzhou

510280

Zhujiang Hospital, Southern Medical University, Guangzhou

510515

Nanfang Hospital, Southern Medical University, Guangzhou

530021

Guangxi Cancer Hospital of Guangxi Medical University, Nanning

The First Affiliate Hospital of Guangxi Medical University, Nanning

603109

Clinical hospital #1, FBHI Volga district medical center, Federal Medical and Biological Agency, Nizhny Novgorod

610041

West China Hospital, Sichuan University, Chengdu

830000

The Tumor Hospital of Xinjiang Medical University, Ürümqi

41253-190

Hospital Sao Rafael - HSR, Salvador

70200-730

Sociedade beneficente de senhoras Hospital Sirio Libanes, Brasília

85806-300

Hospital do Cancer UOPECCAN, Cascavel

01323-020

Hospital Alemao Oswaldo Cruz, São Paulo

V5Z 1M9

Gordon & Leslie Diamond Health Care Centre, Vancouver

H4A 3J1

McGill University Health Centre - Glen Site, Montreal

DUMMY_VALUE

Zhongshan Hospital Fudan Unvierstiy, Shanghai

Northern Jangsu People's Hospital, Yangzhou

625 00

Fakultni nemocnice Brno, Brno

140 59

Fakultni Thomayerova Nemocnice, Prague

Unknown

Prince of Wales Hospital, Shatin

260-8677

Chiba University Hospital, Chiba

790-0024

Ehime Prefectural Central Hospital, Ehime

734-8551

Hiroshima University Hospital, Hiroshima

060-0033

Sapporo Kosei General Hospital, Hokkaido

663-8501

Hyogo Medical University Hospital, Hyōgo

670-8540

Japanese Red Cross Society Himeji Hospital, Hyōgo

920-8641

Kanazawa University Hospital, Ishikawa

232-0024

Yokohama City University Medical Center, Kanagawa

241-8515

Kanagawa Cancer Center, Kanagawa

252-0375

Kitasato University Hospital, Kanagawa

860-8556

Kumamoto University Hospital, Kumamoto

543-8555

Osaka Red Cross Hospital, Osaka

589-8511

Kindai University Hospital, Osaka

770-8503

Tokushima University Hospital, Tokushima

105-8470

Toranomon Hospital, Tokyo

113-8655

The University of Tokyo Hospital, Tokyo

180-8610

Japanese Red Cross Musashino Hospital, Tokyo

6229 HX

Maastricht University Medical Center, Maastricht

02-781

Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie, Warsaw

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06273

Gangnam Severance Hospital, Seoul

06591

Seoul St Mary's Hospital, Seoul

07061

Boramae Medical Center, Seoul

06080

Hospital Universitario Infanta Cristina, Badajoz

01120

Adana Baskent University Hospital, Adana

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT04102098 - A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation | Biotech Hunter | Biotech Hunter