Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial

NARecruitingINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

October 1, 2019

Primary Completion Date

October 1, 2026

Study Completion Date

November 1, 2026

Conditions
Diverticulitis
Interventions
PROCEDURE

Partial Colectomy

Most partial colectomies are performed using a laparoscopic approach, when possible, and surgeons sometimes use a temporary, protective stoma if the re-connection is considered high risk.

OTHER

Medical Management

"Patients will be offered a varying combination of tools from the best medical management toolbox (diet and exercise, fiber supplementation/probiotics, and rifamycin/mesalazine) depending on what they have already tried. Based on the evidence-based best medical toolbox clinicians will be asked to consider rifamycin (dose/frequency) for those with AUD who are not responding to diet and exercise and mesalazine (dose/frequency) for those with lingering symptoms who are not responding to diet and exercise."

Trial Locations (28)

10027

RECRUITING

Columbia University Medical Center, New York

11355

RECRUITING

New York Presbyterian-Queens, Flushing

12208

RECRUITING

Albany Medical College, Albany

14618

RECRUITING

University of Rochester Medical Center, Rochester

15212

RECRUITING

Allegheny-Singer Research Institute, Pittsburgh

19104

RECRUITING

Penn Medicine, Philadelphia

23298

RECRUITING

VCU Medical Center, Richmond

28203

RECRUITING

Atrium Health-Carolinas Medical Center, Charlotte

29425

RECRUITING

Medical University of South Carolina, Charleston

31404

RECRUITING

Memorial Health University Medical Center, Savannah

32608

RECRUITING

University of Florida, Gainesville

33606

RECRUITING

University of South Florida, Tampa

43213

RECRUITING

Mount Carmel Health Systems, Columbus

52242

RECRUITING

University of Iowa Healthcare, Iowa City

60201

RECRUITING

Northwestern University, Evanston

60612

RECRUITING

Rush University Medical Center, Chicago

62794

RECRUITING

Southern Illinois University School of Medicine, Springfield

75390

RECRUITING

UT Southwestern Medical Center, Dallas

80045

RECRUITING

University of Colorado, Denver

84112

RECRUITING

University of Utah Health, Salt Lake City

90048

RECRUITING

Cedars-Sinai Medical Center, Los Angeles

92103

RECRUITING

UC San Diego Health, San Diego

94143

RECRUITING

UCSF Health, San Francisco

94305

RECRUITING

Stanford University Medical Center, Stanford

98101

RECRUITING

Benaroya Research Institute at Virginia Mason, Seattle

98105

RECRUITING

University of Washington, Seattle

02118

RECRUITING

Boston University Medical Center, Boston

01805

RECRUITING

Lahey Clinic, Burlington

All Listed Sponsors
collaborator

Patient-Centered Outcomes Research Institute

OTHER

lead

University of Washington

OTHER