Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

January 28, 2020

Primary Completion Date

February 9, 2023

Study Completion Date

February 9, 2023

Conditions
Adult Solid Tumor
Interventions
BIOLOGICAL

SQZ-PBMC-HPV

antigen presenting cell therapy; therapeutic vaccine consisting of peripheral blood mononuclear cells (PBMCs) manufactured with immunogenic epitopes of HPV16

DRUG

Atezolizumab

programmed cell death ligand 1 (PD-L1) blocking antibody

DRUG

Ipilimumab

cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blocking antibody

DRUG

Nivolumab

programmed cell death 1 (PD-1) blocking antibody

Trial Locations (12)

37212

Vanderbilt University Medical Center, Nashville

50937

University Hospital Cologne, Clinic I for Internal Medicine, Cologne

55455

The Masonic Cancer Center University of Minnesota, Minneapolis

66160

University of Kansas Cancer Center, Kansas City

73104

OU Health Stephenson Cancer Center, Oklahoma City

80045

University of Colorado Anschutz Cancer Pavillion, Aurora

85258

HonorHealth, Scottsdale

90048

Cedars-Sinai Medical Center, Los Angeles

97213

Providence Cancer Institute, Portland

02114

Massachusetts General Hospital, Boston

68198-6840

University of Nebraska Medical Center, Omaha

M5G 2C1

Princess Margaret Cancer Centre, Toronto

All Listed Sponsors
lead

SQZ Biotechnologies

INDUSTRY

NCT04084951 - Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors | Biotech Hunter | Biotech Hunter