Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

675

Participants

Timeline

Start Date

September 20, 2019

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2025

Conditions
Diabetic Cardiomyopathies
Interventions
DRUG

AT-001

"AT-001 will be administered as 3 capsules twice daily, before breakfast and before dinner.~At present AT001 is the sole name for the active substance. No INN/genetic name is available to date"

DRUG

Placebo

Matching placebo will be administered as 3 capsules twice daily, before breakfast and before dinner

Trial Locations (79)

3004

Baker Heart and Diabetes Institute, Melbourne

3084

Austin Health, Heidelberg

3220

Barwon Health-University Hospital Geelong, Geelong

4032

Prince Charles Hospital, Chermside

4064

CORE Research Group Pty. Ltd., Milton

4068

AusTrials, Taringa

7001

University of Tasmania at Hobart, Hobart

10455

Chear Center LLC, The Bronx

10467

Montefiore Medical Center, The Bronx

10787

Klinische Forschung Berlin GbR, Berlin

14004

Hospital Universitario Reina Sofia, Córdoba

15001

Hospital Abente y Lago (Complejo Universitario de la Coruña), A Coruña

15236

Klinikum Frankfurt (Oder) GmbH, Frankfurt (Oder)

29651

Mountain View Clinical Research - Greer, Greer

Mountain View Clinical Research, Greer

30120

Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar

32127

Progressive Medical Research, Port Orange

32545

Herz-und Diabeteszentrum NRW Universitaetsklinik der Ruhr-Universitaet Bochum, Bad Oeynhausen

33016

New Generation of Medical Research, Hialeah

33024

ALL Medical Research, LLC, Cooper City

Broward Research Center, Pembroke Pines

37660

Holston Medical Group, Kingsport

39216

Universty of Mississippi Medical Center, Jackson

41009

Hospital Universitario Virgen Macarena, Seville

43215

Remington Davis, Inc., Columbus

44093

CHU de Nantes, Clinique d'Endocrinologie, Nantes

44195

Cleveland Clinic, Cleveland

46010

Hospital Clinico Universitario de Valencia, Valencia

55101

Edumed s.r.o., Jaroměř

59322

Centre Hospitalier de Valenciennes, Valenciennes

61602

UnityPoint Health - Methodist Hospital, Peoria

63136

St. Louis Heart and Vascular Cardiology, St Louis

73135

South Oklahoma Heart Research, Oklahoma City

75230

Dallas Diabetes Research Center, Dallas

75235

Southwest Family Medicine Associates, Dallas

75390

University of Texas Southwestern, Dallas

76550

FMC Science, Lampasas

77040

Juno Research, LLC - Northwest Site, Houston

77074

Juno Research, LLC - Southwest Houston Site, Houston

90211

Westside Medical Associates of Los Angeles, Beverly Hills

90509

Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance

91356

Metabolic Institute of America, Tarzana

92093

University of California, San Diego (UCSD), La Jolla

92868

University of California - Irvine Medical Center, Orange

93140

Hôpital Jean-Verdier - AP-HP; Service Endocrinologie Diabétologie Nutrition, Bondy

94000

CHU Henri Mondor, Créteil

95648

Clinical Trials Research, Lincoln

02115

Brigham and Women's Hospital, Boston

T2V 4J2

C-Endo - Endocrinology Centre, Calgary

V5Y 3W2

BC Diabetes, Vancouver

L6S 0C6

LMC Diabetes & Endocrinology Ltd. - Brampton, Brampton

L4K 4M2

LMC Diabetes & Endocrinology Ltd. - Thornhill, Concord

M9R 4E1

LMC Diabetes & Endocrinology Ltd. - Etobicoke, Etobicoke

N6G 2M1

Centre for Studies in Family Medicine, Western Centre for Public Health and Family Medicine, Western University, London

M4G 3E8

LMC Diabetes & Endocrinology Ltd. - Toronto, Toronto

G7H 7K9

Ecogene-21, Chicoutimi

G1V 4G5

Institut Universitaire de Cardiologie et de Pneumologie De Quebec, Québec

532 03

Nemocnice Pardubickeho kraje, a.s., Nemocnice Pardubice, Pardubice

128 08

Vseobecna fakultni nemocnice v Praze, Prague

01277

Cardiologicum Pirna und Dresden, Dresden

04910

ZKS - Zentrum Klinische Studien Sudbrandenburg GmbH, Elsterwerda

Unknown

Erik Yee Mun George Fung, Shatin

Prince of Wales Hospital; Chinese University of Hong Kong; Dept of Medicine and Therapeutics, Shatin

50-556

Centrum Chorob Serca w USK, Wroclaw

15-435

NZOZ Specjalistyczny Osrodek Internistyczno - Diabetologiczny, Bialystok

31-506

Topolowa MEDICENTER Mrózek & wspólnicy sp.j., Krakow

31-526

Centrum Twojego Zdrowia, Krakow

90-302

ETG Lodz, Lodz

61-655

Praktyka Lekarska Ewa Krzyzagorska, Poznan

26-600

Prywatny Gabinet Lekarski Centrum Medyczne Diabetika, Radom

35-005

Centrum Medyczne Medyk Stanislaw Mazur Sp. z o.o. SK, Rzeszów

50-981

4 Wojskowy Szpital Kliniczny z Poliklinika Samodzielny Publiczny ZOZ we Wroclawiu, Wroclaw

08916

Hospital Germans Trias i Pujol, Badalona

08041

Hospital de la Santa Creu i Sant Pau Barcelona, Barcelona

DD1 9SY

Ninewells Hospital & Medical School, Dundee

G20 0XA

CPS Research, Glasgow

LE3 9QP

Glenfield hospital, Leicester

EC1M 6BQ

Barts and The London School of Medicine & Dentistry, London

M23 9Lt

Wythenshawe Hospital, Manchester

Sponsors
All Listed Sponsors
lead

Applied Therapeutics, Inc.

INDUSTRY