A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection, 5-fluorouracil/Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer, Compared to Nab-paclitaxel+Gemcitabine Treatment

PHASE3CompletedINTERVENTIONAL
Enrollment

770

Participants

Timeline

Start Date

February 11, 2020

Primary Completion Date

July 23, 2022

Study Completion Date

February 18, 2025

Conditions
Metastatic Adenocarcinoma of the Pancreas
Interventions
DRUG

Irinotecan Liposomal Injection

Irinotecan liposome injection is irinotecan in the form of the sucrosofate salt, encapsulated in liposomes for i.v. infusion. It is supplied in sterile, single-use vials containing 10 mL of irinotecan liposome injection at a concentration of 4.3 mg/mL free base equivalent (FBE).

DRUG

Oxaliplatin

Oxaliplatin injection, USP is supplied in single-dose vials containing 50 mg, 100 mg or 200 mg of oxaliplatin as a sterile, preservative-free, aqueous solution at a concentration of 5 mg/mL.

DRUG

5Fluorouracil

Fluorouracil injection, USP is a colorless to faint yellow, aqueous, sterile, nonpyrogenic injectable solution available in 50 mL and 100 mL pharmacy bulk package. Each mL contains 50 mg fluorouracil in water for injection, USP.

DRUG

Leucovorin

Leucovorin Calcium for Injection is supplied in vials ranging from 50-500 mg and available as an injectable solution or lyophilized powder for reconstitution.

DRUG

Nab-paclitaxel

Nab-paclitaxel is a lyophilised powder containing 100 or 250 mg of paclitaxel formulated as albumin-bound particles in single-use vials for re-constitution. Each mL of the reconstituted formulation will contain 5 mg/mL paclitaxel.

DRUG

Gemcitabine

Gemcitabine for injection is a lyophilised powder for solution for infusion, with each single use vial containing 200 mg, 1 g or 2 g of gemcitabine.

Trial Locations (200)

1090

Medical University of Vienna, Vienna

1097

Dél-pesti Centrumkórház - Szent László Kórház telephely, Budapest

1122

Országos Onkológiai Intézet, Budapest

2200

Bankstown-Lidcombe Hospital, Bankstown

2650

Universitair Ziekenhuis Antwerpen (UZA), Edegem

3000

University Hospital (UZ) Leuven, Leuven

3168

Monash Medical Centre, Clayton

4010

Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz

5011

Queen Elizabeth Hospital, Woodville South

5416

CIP Centro Integrado de Pesquisas do Hospital de Base, São José do Rio Preto

5530

University Hospital Mont-Godinne, Yvoir

6000

ASBL Grand Hôpital de Charleroi (GHdC), Site Notre Dame, Charleroi

6008

St John of God Subiaco Hospital, Subiaco

6009

Sir Charles Gairdner Hospital, Nedlands

6150

Fiona Stanley Hospital, Murdoch

7100

Hospital centre Jolimont, Haine-Saint-Paul

7400

Somogy Megyei Kaposi Mor Oktato Korhaz, Kaposvár

8036

Medizinische Universitaet Graz, Graz

9000

University Hospital Gent, Ghent

9300

Onze-Lieve-Vrouwziekenhuis, Aalst

10021

Clinical Research Alliance, Inc, Lake Success

10065

David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York

10117

Charité - Universitaetsmedizin Berlin, Berlin

10408

National Cancer Center, Goyang-si

11522

Agios Savvas Anticancer Hospital, Athens

11528

General Hospital of Athens - Laiko, Athens

National and Kapodistrian University of Athens, Athens

11794

Stony Brook University Medical Center, Stony Brook

13520

CHA Bundang Medical Center, Gyeonggi-do

14059

Thomayerova Nemocnice, Prague

14642

University of Rochester, Rochester

15232

University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center, Pittsburgh

18014

Complejo Hospitalario Universitario de Granada - Hospital Universitario Virgen de las Nieves, Granada

20141

Istituto Europeo di Oncologia, Milan

20249

Facharztzentrum Eppendorf, Hamburg

20904

Maryland Oncology Hematology, Silver Spring

22031

Virginia Cancer Specialists, Fairfax

22087

Marienkrankenhaus Hamburg, Hamburg

22763

Asklepios Klinik Altona, Hamburg

24014

Blue Ridge Cancer Care, Wytheville

28007

Hospital General Universitario Gregorio Marañon, Madrid

28040

Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28050

Centro Integral Oncologico Clara Campal, Madrid

28806

Messino Cancer Center, Asheville

29009

Hospital Regional Universitario de Malaga, Málaga

29121

AUSL di Piacenza-Ospedale Guglielmo Da Saliceto, Piacenza

29605

Greenville Hospital System, Greenville

30625

Medizinische Hochschule Hannover, Hanover

31008

Complejo Hospitalario de Navarra, Pamplona

32308

Florida Cancer Specialists - Panhandle, Tallahassee

33140

Mount Sinai Medical Center of Florida, Inc., Miami Beach

33176

Miami Cancer Institute, Miami

33401

Florida Cancer Specialists - East, West Palm Beach

33604

CHU Bordeaux - Hopital Haut-Leveque, Pessac

33607

Florida Cancer Specialists - St. Petersburg, Tampa

34236

Florida Cancer Specialists - Fort Myers, Sarasota

35294

University of Alabama at Birmingham, Birmingham

37134

Azienda Ospedaliera - Universitaria Integrata di Verona - Ospedale Borgo Roma, Verona

37170

CHRU de Tours - Hôpital Trousseau, Chambray-lès-Tours

37203

Sarah Cannon and HCA Research Institute, Nashville

37404

Chattanooga Oncology Hematology Care - Tennessee Oncology, Chattanooga

38138

The West Cancer Center, Memphis

39008

Hospital Universitario Marques de Valdecilla, Santander

40138

Policlinico S. Orsola-Malpighi, Bologna

40536

University of Kentucky Markey Cancer Center, Lexington

41063

Krankenhaus St. Franziskus - Kliniken Maria Hilf GmbH, Mönchengladbach

41124

Azienda Ospedaliero-Universitaria di Modena, Modena

41501

Pikeville Medical Center, Pikeville

43210

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solovev Research Institute (OSUCCC - James), Columbus

43623

Toledo Clinic Cancer Center, Toledo

44791

St. Josef-Hospital, Bochum

45500

University General Hospital of Ioannina, Ioannina

46804

Fort Wayne Medical Oncology and Hematology, Fort Wayne

47014

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori, Meldola

48108

Inje University Haeundae Paik Hospital, Busan

48202

Henry Ford Health System, Detroit

49546

Cancer and Hematology Centers of Western Michigan, Grand Rapids

50005

Fakultni nemocnice Hradec Kralove, Hradec Králové

50009

Hospital Universitario Miguel Servet, Zaragoza

51101

Siouxland Hematology - Oncology Associates, LLP, Sioux City

53226

Froedtert Hospital and the Medical College of Wisconsin, Milwaukee

54007

Theagenion Hospital, Thessaloniki

55425

Health Partners Institute, Minneapolis

55902

Mayo Clinic - Rochester, Rochester

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

59020

Centre Oscar Lambret, Lille

59102

Frontier Cancer Center, Billings

60126

AOU Ospedali Riuniti di Ancona, Torrette

60488

Krankenhaus Nordwest, Frankfurt

60540

Edward Hospital - Elmhurst, Elmhurst

60612

Rush University Medical Center, Chicago

61443

Illinois CancerCare - Peoria, Peoria

61801

Carle Cancer Center, Urbana

64132

Research Medical Center, Kansas City

65653

Masarykuv onkologicky ustav, Brno

67000

Strasbourg Oncologie Liberale, Strasbourg

68130

Oncology Hematology West P.C. dba Nebraska Cancer Specialists, Omaha

68167

Klinikum Mannheim, Mannheim

69003

Hôpital Edouard Herriot, Lyon

69008

Centre Leon Berard, Lyon

Hopital Prive Jean Mermoz, Lyon

70121

Ochsner Clinic Foundation, New Orleans

70809

Hematology Oncology Clinic, Baton Rouge

71103

Willis-Knighton Cancer Center, Shreveport

72076

Universitaetsklinikum Tuebingen, Tübingen

73104

University of Oklahoma - Health Sciences Center, Oklahoma City

73730

Klinikum Esslingen GmbH, Esslingen am Neckar

74078

Slk-Kliniken, Heilbronn

75010

Hopital Saint Louis, Paris

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

75702

Texas Oncology - Tyler, Tyler

76104

The Center for Cancer and Blood Disorders, Fort Worth

76310

Texas Oncology - Wichita Falls, Wichita Falls

77020

University Hospital Olomouc, Department of Oncology, Olomouc

77030

Baylor College of Medicine, Houston

Houston Methodist Research Institute, Houston

MD Anderson Cancer Center, Houston

Oncology Consultants, Houston

78731

Texas Oncology - Austin, Austin

80218

Rocky Mountain Cancer Center, Denver

80909

UC Health Memorial Hospital, Colorado Springs

84106

Utah Cancer Specialists, Salt Lake City

85054

Mayo Clinic - Scottsdale, Phoenix

85234

Banner Health- MD Anderson Cancer Center, Gilbert

86021

Centre Hospitalier Universitaire de Poitiers - Poitiers University Hospital, Poitiers

89081

Universitaetsklinikum Ulm, Ulm

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90095

University of California, Los Angeles (UCLA), Los Angeles

90277

Torrance Memorial Physician Network Cancer Care, Redondo Beach

90602

Presbyterian Intercommunity Hospital (PIH), Whittier

91010

City of Hope National Medical Center, Duarte

92627

University of California- Irvine Health Cancer Cente, Costa Mesa

92835

St. Jude Hospital Yorba Linda dba St. Joseph Heritage Healthcare, Orange

92868

University of California - Irvine Medical Center, Orange

93309

Comprehensive Blood And Cancer Center, Bakersfield

95816

Sutter Health Sacramento, Sacramento

95900

Hospital Bruno Born, Lajeado

97227

Compass Oncology - Rose Quarter Cancer Center, Portland

Kaiser Permanente - Northwest, Portland

97239

Oregon Health & Science University (OHSU), Portland

97401

Oncology Associates of Oregon, Eugene

98700

Hospital de Caridade de Ijui, Ijuí

105229

Main Military Clinical Hospital named after N.N. Burdenko, Moscow

305524

Kursk Regional Clinical Oncology Dispensary, Kursk

420126

Limited Liability Company- Clinica Druzhkovyh, Kazan'

454048

Evimed LLC, Chelyabinsk

603074

Volga District Medical Centre, Veliky Novgorod

3109601

Rambam Health Care Campus, Haifa

04074

Maine Center for Cancer Medicine, Scarborough

02215

Beth Israel Deaconess, Boston

A-5020

SCRI-CCCIT Gemeinnutzige Gmbh- Gemeinnutzige Salzburger Landeskliniken Betriebsgesmbh, Salzburg

14784-400

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

60336-550

Centro Regional Integrado de Oncologia (CRIO), Ceará

80530-010

Instituto de Oncologia do Parana - IOP, Curitiba

88034-000

Centro de Pesquisas Oncológicas - CEPON, Florianópolis

88301-220

Clinica Neoplasias Litoral, Itajaí

59025-050

Centro de Pesquisas Clinicas de Natal - CPCLIN, Natal

Unknown

Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre

Instituto do Cancer do Estado de São Paulo (ICESP), São Paulo

Federal State Budgetary Institution - Russian Scientific Center of Radiology and Surgical Technologies n.a. academician A.M.Granov, Saint Petersburg

20230-130

Instituto Nacional Do Cancer (INCA), Rio de Janeiro

22793-080

Instituto COI, Rio de Janeiro

01323-001

Hospital Alemão Oswaldo Cruz, São Paulo

03102-006

Instituto Brasileiro de Controle do Cancer - IBCC (Sao Paulo), São Paulo

T6G 1Z2

Alberta Health Services Cross Cancer Institute, Edmonton

B3H 3A7

Queen Elizabeth II Health Sciences Centre, Halifax

H3G 1Y6

McGill University Faculty of Medicine - Royal Victoria Hospital, Montreal

J1H 5N4

Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke

06189

Centre Antoine-Lacassagne, Nice

06108

Studiengesellschaft BSF, Halle

06120

Martin Luther Universitat Halle-Wittenberg, Halle

H-1089

Semmelweis Egyetem Belgyógyászati és Hematológiai Klinika, Budapest

H-4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

H-5000

Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendelointézet, Szolnok

Beer Sheva

Soroka Medical Center, Beersheba

4710-243

Hospital de Braga, Braga

1400-038

Champalimaud Cancer Center, Lisbon

1649-035

Centro Hospitalar Universitario de Lisboa Norte - Hospital de Santa Maria, Lisbon

4464-513

Unidade Local de Saude Matosinhos E.P.E. Hospital Pedro Hispano, Senhora da Hora

4434-502

Centro Hospitalar de Vila Nova de Gaia/Espinho EPE, Vila Nova de Gaia

05505

Asan Medical Center, Seoul

06591

Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul

08308

Korea University Guro Hospital, Seoul

03203

Hospital General Universitario de Elche, Alicante

06080

Hospital Universitario de Badajoz, Badajoz

08916

Hospital Germans Trias i Pujol, Badalona

08023

Hospital Quironsalud Barcelona, Barcelona

08026

Hospital de la Santa Creu i Sant Pau Barcelona, Barcelona

08035

Hospital Vall D Hebron, Barcelona

08036

Hospital Clinic Barcelona, Barcelona

08208

Corporacio Sanitaria Parc Tauli - Hospital de Sabadell, Barcelona

08908

Institut Catala d'Oncologia - L'Hospitalet, Barcelona

SE1 9RT

Guy's and St. Thomas' NHS Foundation Trust, London

SM2 5PT

Royal Marsden Foundation Trust, London

SW3 6JJ

Royal Marsden Foundation Trust, London

W12 0HS

Imperial College Healthcare NHS Trust, London

M20 4BX

Cancer Research UK - Christie Hospital Foundation NHS Trust - Dept of Medical Oncology, Manchester

NG5 1PB

Nottingham City Hospital, Nottingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Ipsen

INDUSTRY