3,208
Participants
Start Date
January 15, 2020
Primary Completion Date
December 30, 2024
Study Completion Date
December 31, 2025
IVIG
IVIG at a single dose of 2 g/kg, with the maximum dose of 60g
Aspirin
Aspirin 30 mg/kg in oral per day (given in 3 divided doses), then 3 to 5 mg/kg per day when fever subsides for 3 days and C-reactive protein (CRP) is normal. Aspirin will be continued for at least 6 weeks after onset of illness.
Prednisolone
Intravenous methylprednisolone 1.6 mg/kg per day (given in 2 divided doses, with the maximum dose 60mg of prednisolone ) for 3 days, then changed to oral prednisolone 2 mg/kg when fever subsides for 3 days. If CRP is normal, the oral dose will be reduced every 5 days from 2 mg/kg to 1 mg/kg to 0.5 mg/kg (tapered over 15 days). Then prednisolone will be discontinued.
Children's Hospital, Capital Institute of Pediatrics, Beijing
Shengjing Hospital of China Medical University, Shenyang
The First Hospital of Jilin University, Changchun
Shanghai Children's Hospital, Shanghai
Children's Hospital of Fudan University, Shanghai
Children's Hospital of Nanjing Medical University, Nanjing
Children's hospital of Soochow University, Suzhou
Xuzhou Children's Hospital, Xuzhou
Anhui Children's Hospital, Hefei
Bengbu First People's Hopital, Bengbu
Qilu Hospital of Shandong University, Jinan
Qingdao Women and Children's Hospital (Liaoyang West Road), Qingdao
Qingdao Women and Children's Hospital, Qingdao
Hangzhou First people's Hospital, Hangzhou
Yuying Children's Hospital of Wenzhou Medical University, Wenzhou
Jiangxi Provincial Children's Hospital, Nanchang
Xiamen Children's Hospital, Xiamen
Children's Hospital of Chongqing Medical University, Chongqing
Hunan Provincial People's Hospital, Changsha
Union Hospital,Tongji Medical College of Huazhong University of Science and Technology, Wuhan
Taihe Hospital Affiliated Hospital of Hubei University of Medicine, Shiyan
Henan Children's Hospital, Zhengzhou
the First Affiliated Hospital of Zhengzhou University, Zhengzhou
The Third Affiliated Hospital of Zhengzhou University, Zhengzhou
Kaifeng Children's Hospital, Kaifeng
Sun Yat-sen Memorial Hospital, Guangzhou
Guangzhou Women and Children's Medical Center, Guangzhou
Shenzhen Children's Hospital, Shenzhen
Liuzhou Maternity and Children Healthcare Hospital, Liuzhou
Sichuan Provincial People's Hospital, Chengdu
Chengdu Women's and Children's Central Hospital, Chengdu
Xi'an Children's Hospital, Xi'an
Lanzhou University Second Hospital, Lanzhou
Inner Mongolia People's Hospital, Hohhot
Jiangxi Province Children's Hospital
OTHER
First People's Hospital of Hangzhou
OTHER
Shengjing Hospital
OTHER
The First Hospital of Jilin University
OTHER
Chengdu Women's and Children's Central Hospital
OTHER
Children's Hospital of Chongqing Medical University
OTHER
Inner Mongolia People's Hospital
OTHER
Sichuan Provincial People's Hospital
OTHER
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
OTHER
Third Affiliated Hospital of Zhengzhou University
OTHER
Children's Hospital of Soochow University
OTHER
Yuying Children's Hospital of Wenzhou Medical University
OTHER
Beijing Children's Hospital
OTHER
Qilu Hospital of Shandong University
OTHER
Children's Hospital of Fudan University
OTHER