Intrauterine Flushing With Follicular Fluid Plus Granulosa Cells

PHASE3CompletedINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

November 1, 2018

Primary Completion Date

December 1, 2022

Study Completion Date

January 1, 2023

Conditions
Follicular FluidGranulosa CellEmbryo Implantation
Interventions
BIOLOGICAL

Intrauterine flushing of follicular fluid with granulosa cells

All patients in case and control groups will receive agonist and antagonist protocol. Ovarian stimulation will be carried out when pituitary desensitization is achieved and is continued until the day of hCG administration. COCs aspiration will be performed 34-36h after hCG injection. Clear Follicular Fluids (without blood cells) which contain COCs will be used. Endometrial flushing after oocyte retrieval with 2 ml of clear FF plus granulose cells will be performed by an IUI catheter. The control group included 70 women who would not have FF endometrial flushing. In both groups, embryo transfer will be carried out 2-3 days later. Luteal phase support will be started the day after ovum pick up by the vaginal administration of progesterone daily for 16 days and will continued for up to12 weeks if pregnancy occurred. Pregnancy was diagnosed by measurement of β-hCG level and later was confirmed by Transvaginal sonography.

Trial Locations (1)

Unknown

Royan Institute, Tehran

All Listed Sponsors
lead

Royan Institute

OTHER_GOV

NCT04077970 - Intrauterine Flushing With Follicular Fluid Plus Granulosa Cells | Biotech Hunter | Biotech Hunter