A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

701

Participants

Timeline

Start Date

September 4, 2019

Primary Completion Date

June 3, 2026

Study Completion Date

June 3, 2026

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Lazertinib

Lazertinib will be administered orally.

DRUG

Amivantamab

Amivantamab will be administered as an intravenous (IV) infusion.

DRUG

Carboplatin

Carboplatin will be administered as IV infusion.

DRUG

Pemetrexed

Pemetrexed will be administered as IV infusion.

Trial Locations (78)

402

Chung Shan Medical University Hospital, Taichung

704

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

8035

Hosp Univ Vall D Hebron, Barcelona

10002

National Taiwan University Hospital, Taipei

10016

Langone Health at NYC University, NYU School of Medicine, New York

10032

Columbia University Medical Center, New York

13005

CHU de la Timone, Marseille

13125

Evangelische Lungenklinik Berlin, Berlin

13620

Seoul National University Bundang Hospital, Seongnam-si

19104

University of Pennsylvania Division of Hematology Oncology Perelman Center for Advanced Medicine, Philadelphia

20052

San Gerardo Hospital, Monza

20132

IRCCS Ospedale San Raffaele, Milan

22031

Virginia Cancer Specialists, Fairfax

26121

Pius-Hospital Oldenburg, Oldenburg

28009

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28034

Hosp. Univ. Ramon Y Cajal, Madrid

28040

Hosp Univ Fund Jimenez Diaz, Madrid

28041

Hosp. Univ. 12 de Octubre, Madrid

28050

Hosp Univ Hm Sanchinarro, Madrid

33000

Institut Bergonie, Bordeaux

33612

H. Lee Moffitt Cancer & Research Institute, Tampa

41013

Hosp. Virgen Del Rocio, Seville

45147

Universitaetsklinikum Essen, Essen

48121

Ospedale S. Maria Delle Croci, Ravenna

48201

Barbara Ann Karmanos Cancer Institute, Detroit

50937

Uniklinik Köln, Cologne

51109

Kliniiken der Stadt Köln gGmbH, Krankenhaus Köln-Mehrheim, Cologne

58675

Lungenklinik Hemer, Hemer

60590

Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main

63110

Washington University School Of Medicine, St Louis

69373

Centre Leon Berard, Lyon

70376

Robert-Bosch-Krankenhaus - Klinik Schillerhoehe, Stuttgart

75005

Institut Curie, Paris

80131

Istituto Nazionale Tumori Fondazione G. Pascale, Napoli

82131

Asklepios Klinik Gauting GmbH - Asklepios Fachkliniken Munchen-Gauting, Gauting

84112

Huntsman Cancer Institute, Salt Lake City

86000

CHU De Poitiers, Poitiers

90033

USC Norris Comprehensive Cancer Center, Los Angeles

90048

Cedars Sinai Medical Center, West Hollywood

92868

University of California Irvine, Orange

94158

UCSF Helen Diller Comprehensive, San Francisco

94163

HIA Begin, Saint-Mandé

94305

Stanford University Medical Center, Stanford

94805

Institut Gustave Roussy, Villejuif

97213

Providence Portland Medical Center, Portland

98109

University of Washington, Seattle

100142

Beijing Cancer Hospital, Beijing

110022

Shengjing Hospital Of China Medical University, Shenyang

130021

The First Bethune Hospital of Jilin University, Changchun

200030

Shanghai Chest Hospital, Shanghai

250013

Central Hospital of Jinan, Jinan

300000

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310022

Zhejiang Cancer Hospital, Hangzhou

400030

Chongqing University Cancer Hospital, Chongqing

410013

Hunan Cancer hospital, Changsha

430022

Union Hospital Tongji Medical College of Huazhong University of Science and Technology, Wuhan

440112

The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou

610041

West China School of Medicine/West China Hospital, Sichuan University, Chengdu

650101

The Second Affiliated Hospital of Kunming Medical University, Kunming

710061

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

02114

Massachusetts General Hospital, Boston

02118

Boston University Medical Center, Boston

02215

Dana Farber Cancer Institute, Boston

06120

Städtisches Krankenhaus Martha-Maria Halle-Dölau gGmbH, Halle

Unknown

IRCCS Istituto Europeo di Oncologia, Milan

104 0045

National Cancer Center Hospital, Chūōku

573 1191

Kansai Medical University Hospital, Hirakata

277 8577

National Cancer Center Hospital East, Kashiwa

650 0047

Kobe City Medical Center General Hospital, Kobe

464 8681

Aichi Cancer Center Hospital, Nagoya

700 8558

Okayama University Hospital, Okayama

411 8777

Shizuoka Cancer Center, Shizuoka

OO935

Oncologic Hospital, Puerto Rico Medical Center, Rio Piedras

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

06351

Samsung Medical Center, Seoul

08028

Hosp. Univ. Quiron Dexeus, Barcelona

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY