NCT04071236View on ClinicalTrials.gov

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

October 14, 2020

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2026

Conditions
Metastatic Castration-Resistant Prostate CarcinomaMetastatic Malignant Neoplasm in the BoneMetastatic Malignant Neoplasm in the Lymph NodesStage IVB Prostate Cancer AJCC v8
Interventions
DRUG

Avelumab

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Bone Scan

Undergo bone scan

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Peposertib

Given PO

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Radium Ra 223 Dichloride

Given IV

Trial Locations (30)

10016

ACTIVE_NOT_RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

19107

ACTIVE_NOT_RECRUITING

Thomas Jefferson University Hospital, Philadelphia

30308

ACTIVE_NOT_RECRUITING

Emory University Hospital Midtown, Atlanta

30322

ACTIVE_NOT_RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

ACTIVE_NOT_RECRUITING

Emory Saint Joseph's Hospital, Atlanta

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

48201

SUSPENDED

Wayne State University/Karmanos Cancer Institute, Detroit

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64116

ACTIVE_NOT_RECRUITING

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

66160

ACTIVE_NOT_RECRUITING

University of Kansas Cancer Center, Kansas City

66205

ACTIVE_NOT_RECRUITING

University of Kansas Clinical Research Center, Fairway

ACTIVE_NOT_RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

ACTIVE_NOT_RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

ACTIVE_NOT_RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

03756

ACTIVE_NOT_RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH