Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

PHASE2RecruitingINTERVENTIONAL
Enrollment

134

Participants

Timeline

Start Date

July 29, 2020

Primary Completion Date

October 1, 2026

Study Completion Date

October 1, 2026

Conditions
Advanced Renal Cell CarcinomaChromophobe Renal Cell CarcinomaClear Cell Renal Cell CarcinomaCollecting Duct CarcinomaKidney Medullary CarcinomaMetastatic Malignant Neoplasm in the BonePapillary Renal Cell CarcinomaStage IV Renal Cell Cancer AJCC v8Unclassified Renal Cell Carcinoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood and urine sample collection

PROCEDURE

Bone Scan

Undergo bone scan

DRUG

Cabozantinib S-malate

Given PO

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo FDG-PET or NaF-PET

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Radium Ra 223 Dichloride

Given IV

Trial Locations (46)

10065

SUSPENDED

NYP/Weill Cornell Medical Center, New York

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

RECRUITING

UPMC-Shadyside Hospital, Pittsburgh

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

RECRUITING

Duke University Medical Center, Durham

35233

RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48202

ACTIVE_NOT_RECRUITING

Henry Ford Hospital, Detroit

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

52242

ACTIVE_NOT_RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

55109

RECRUITING

Minnesota Oncology Hematology PA-Maplewood, Maplewood

55337

RECRUITING

Minnesota Oncology - Burnsville, Burnsville

60153

SUSPENDED

Loyola University Medical Center, Maywood

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60612

RECRUITING

Rush MD Anderson Cancer Center, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64154

RECRUITING

University of Kansas Cancer Center - North, Kansas City

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

SUSPENDED

University of Kansas Cancer Center-Overland Park, Overland Park

70006

RECRUITING

East Jefferson General Hospital, Metairie

SUSPENDED

LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie

70112

RECRUITING

Tulane University School of Medicine, New Orleans

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75080

RECRUITING

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75237

RECRUITING

UT Southwestern Simmons Cancer Center - RedBird, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

01655

RECRUITING

UMass Memorial Medical Center - University Campus, Worcester

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH