Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

103

Participants

Timeline

Start Date

April 7, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Locally Advanced Malignant Solid NeoplasmLocally Advanced Unresectable CholangiocarcinomaLocally Advanced Unresectable Gallbladder CarcinomaLocally Advanced Unresectable Malignant Solid NeoplasmMetastatic CholangiocarcinomaMetastatic Gallbladder CarcinomaMetastatic Malignant Solid NeoplasmStage III Gallbladder Cancer AJCC v8Stage IV Gallbladder Cancer AJCC v8Unresectable Malignant Solid Neoplasm
Interventions
DRUG

Avelumab

Given IV

PROCEDURE

Biopsy Procedure

Undergo biopsy of tumor

PROCEDURE

Biospecimen Collection

Correlative studies

PROCEDURE

Computed Tomography

Undergo CT scan

RADIATION

Hypofractionated Radiation Therapy

Undergo hypofractionated RT

DRUG

Peposertib

Given PO

Trial Locations (46)

10016

RECRUITING

Bellevue Hospital Center, New York

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

RECRUITING

NYP/Weill Cornell Medical Center, New York

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20007

RECRUITING

MedStar Georgetown University Hospital, Washington D.C.

20016

RECRUITING

Sibley Memorial Hospital, Washington D.C.

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

30308

RECRUITING

Emory University Hospital Midtown, Atlanta

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

RECRUITING

Emory Saint Joseph's Hospital, Atlanta

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

48201

ACTIVE_NOT_RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48334

ACTIVE_NOT_RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

60611

RECRUITING

Northwestern University, Chicago

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

SUSPENDED

University of California Davis Comprehensive Cancer Center, Sacramento

06418

RECRUITING

Smilow Cancer Hospital-Derby Care Center, Derby

06824

RECRUITING

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

RECRUITING

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06830

RECRUITING

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

RECRUITING

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

RECRUITING

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06510

RECRUITING

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

RECRUITING

Yale University, New Haven

06473

RECRUITING

Yale-New Haven Hospital North Haven Medical Center, North Haven

06902

RECRUITING

Smilow Cancer Hospital Care Center at Long Ridge, Stamford

06790

RECRUITING

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

RECRUITING

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

RECRUITING

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

RECRUITING

Smilow Cancer Hospital Care Center - Waterford, Waterford

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

02891

RECRUITING

Smilow Cancer Hospital Care Center - Westerly, Westerly

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT04068194 - Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies | Biotech Hunter | Biotech Hunter