A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

413

Participants

Timeline

Start Date

November 5, 2019

Primary Completion Date

December 15, 2027

Study Completion Date

December 15, 2027

Conditions
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMixed Lineage Acute LeukemiaMixed Phenotype Acute LeukemiaAcute Leukemia of Ambiguous Lineage
Interventions
DRUG

revumenib

revumenib orally

DRUG

cobicistat

Phase 1 Arm C participants will receive 150 mg cobicistat daily.

Trial Locations (57)

2065

RECRUITING

Royal North Shore Hospital, Saint Leonards

3000

RECRUITING

Peter MacCallum Cancer Centre (PMCC), Melbourne

3004

RECRUITING

Alfred Hospital, Melbourne

3050

RECRUITING

Royal Melbourne Hospital (RMH), Parkville

6009

RECRUITING

Sir Charles Gairdner Hospital, Nedlands

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10467

RECRUITING

Montefiore Medical Center, New York

17475

RECRUITING

Universitaetsmedizin Greifswald, Greifswald

19104

RECRUITING

University of Pennsylvania, Philadelphia

20141

RECRUITING

IRCCS-Istituto Europeo di Oncologia, Milan

20246

RECRUITING

Universitaetsklinikum Hamburg-Eppendorf, Hamburg

27110

RECRUITING

Duke University Medical Center, Durham

30322

RECRUITING

Emory Winship Cancer Institute, Atlanta

30329

COMPLETED

Children's Healthcare of Atlanta, Atlanta

33162

COMPLETED

Moffitt Cancer Center, Tampa

33604

RECRUITING

Centre Hospitalier Universitaire (CHU) de Bordeaux, Pessac

34232

RECRUITING

Florida Cancer Specialists and Research Institute, Sarasota

36100

RECRUITING

S Bortolo Hospital AULSS 8 Berica, Vicenza

40138

RECRUITING

IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna

41013

RECRUITING

Hospital Universitario Virgen del Rocio, Seville

43201

RECRUITING

Ohio State University, Columbus

45147

WITHDRAWN

Universitaetsklinikum Essen (AoR), Essen

45267

RECRUITING

University of Cincinnati, Cincinnati

46026

RECRUITING

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

47014

RECRUITING

Istituto Romagnolo Per Lo Studio dei tumori Dino Amadori, Meldola

52246

RECRUITING

University of Iowa hospital, Iowa City

52621

RECRUITING

Sheba Medical Center, Ramat Gan

55131

RECRUITING

Universitaetsmedizin Der Johannes, Gutenberg

60637

RECRUITING

The University of Chicago Medical Center, Chicago

63110

RECRUITING

Washington University in St. Louis School of Medicine, St Louis

69495

RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

75010

RECRUITING

Hospital Saint-Louis - APHP, Paris

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

80045

RECRUITING

University of Colorado, Aurora

84112

COMPLETED

Huntsman Cancer Institute at the University of Utah, Salt Lake City

89081

RECRUITING

University Hospital Of Ulm, Universitatsklinikum Ulm, Ulm

90033

RECRUITING

University Of California Care Medical Group - Norris Comprehensive Cancer Center And Hospital, Los Angeles

90419

RECRUITING

Klinikum Nuernberg Nord, Nuremberg

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

94305

RECRUITING

Stanford Cancer Institute, Palo Alto

94805

RECRUITING

Institut Gustave Roussy-Gustave Roussy Cancer Center -DITEP, Villejuif

97239

RECRUITING

Oregon Health & Science University, Portland

2210010

RECRUITING

Galilee Medical Center, Nahariya

3109601

RECRUITING

Rambam Health Care Campus (RHCC, Haifa

4941492

RECRUITING

Rabin Medical Center, Petah Tikva

9103102

RECRUITING

Shaare Zedek Medical Center, Jerusalem

9112001

RECRUITING

Hadassah Medical Center- Ein Kerem, Jerusalem

02215

RECRUITING

Dana Farber Cancer Institute, Boston

07601

COMPLETED

Hackensack University Medical Center, Hackensack

M5G 2M9

RECRUITING

University Health Network, Toronto

Unknown

RECRUITING

The Hospital for Sick Children, Toronto

04103

RECRUITING

University of Leipzig, Leipzig

00168

RECRUITING

Universita Cattolica Fondazione Policlinico Agostino Gemelli, Roma

08661

RECRUITING

Vilnius University Hospital Santaros Klinikos, Vilnius

3584 CS

RECRUITING

Princess Maxima Center for Pediatric Oncology, Utrecht

00935

RECRUITING

Hospital Centro Comprensivo de Cancer UPR, San Juan

08908

RECRUITING

Institut Catala d'Oncologia (ICO) - Hospital Duran i Reynals, L'Hospitalet de Llobregat

Sponsors
All Listed Sponsors
lead

Syndax Pharmaceuticals

INDUSTRY