665
Participants
Start Date
August 12, 2019
Primary Completion Date
May 12, 2028
Study Completion Date
May 12, 2028
Luspatercept
Luspatercept (ACE-536), an erythroid maturation agent, is a recombinant fusion protein consisting of a modified form of the extracellular domain (ECD) of the human activin receptor type IIB (ActRIIB) linked to the human immunoglobin G 1 (IgG1) Fc domain. ActRIIB receptor and its ligands are members of the transforming growth factor-β (TGF-β) superfamily. Members of the TGF-β superfamily ligands, through their binding to activin receptors, are involved in modulating the differentiation of late-stage erythrocyte precursors (normoblasts) in the bone marrow. Luspatercept for injection is formulated as a sterile, preservative-free, lyophilized cake/powder. Luspatercept for injection is available in 25 mg and 75 mg vials and when reconstituted with water for injection, each consists of 50 mg/mL luspatercept in a 10 mM citrate buffer-based solution
COMPLETED
Local Institution - 465, Roma
COMPLETED
Local Institution - 760, Kaohsiung, San Ming Dist.
RECRUITING
Bone Marrow Transplant Center, Tunis
RECRUITING
Aziza Othmana Hospital, Tunis
RECRUITING
Military Hospital of Tunis, Tunis
COMPLETED
Local Institution - 220, Boulevard
RECRUITING
Royal Prince Alfred Hospital, Camperdown
COMPLETED
Local Institution - 182, Brasschaat
COMPLETED
Local Institution - 184, Leuven
COMPLETED
Local Institution - 102, Clayton
COMPLETED
Local Institution - 221, Plovdiv
RECRUITING
University Hospital Farhat Hached, Sousse
COMPLETED
Local Institution - 100, South Brisbane
RECRUITING
Royal Adelaide Hospital, Adelaide
COMPLETED
Local Institution - 180, Bruges
COMPLETED
Local Institution - 685, Barcelona
COMPLETED
Local Institution - 183, Ghent
RECRUITING
Azienda Ospedaliero Universitaria S. Luigi Gonzaga, Orbassano
COMPLETED
Local Institution - 969, New York
RECRUITING
Chulalongkorn University Faculty of Medicine - King Chulalongkorn Memorial Hospital, Bangkok
RECRUITING
Siriraj Hospital Mahidol University, Bangkok
COMPLETED
Local Institution - 384, Athens
COMPLETED
Local Institution - 301, Marseille
COMPLETED
Local Institution - 341, Berlin
COMPLETED
Local Institution - 470, Allessandria
RECRUITING
Ente Ospedaliero Ospedali Galliera - Centro della Microcitemia e delle Anemie Congenite, Genoa
COMPLETED
Local Institution - 425, Afula
COMPLETED
Local Institution - 972, Philadelphia
WITHDRAWN
Local Institution - 474, Rozzano
RECRUITING
Maggiore Polyclinic Hospital, IRCCS Ca' Granda, Milan
COMPLETED
Local Institution - 472, Varese
COMPLETED
Local Institution - 342, Hamburg
COMPLETED
Local Institution - 421, Nahariya
COMPLETED
Local Institution - 383, Rio Patras
COMPLETED
Local Institution - 469, Pavia
COMPLETED
Local Institution - 687, Madrid
COMPLETED
Local Institution - 344, Hanover
RECRUITING
Hospital Raja Permaisuri Bainun, Ipoh
COMPLETED
Local Institution - 309, Toulouse
COMPLETED
Local Institution - 682, Oviedo
COMPLETED
Local Institution - 883, Mersin
WITHDRAWN
Local Institution - 307, Pessac
COMPLETED
Local Institution - 975, Tampa
COMPLETED
Local Institution - 882, Istanbul
COMPLETED
Local Institution - 884, Istanbul
COMPLETED
Local Institution - 880, Izmir
COMPLETED
Local Institution - 684, Salamanca
WITHDRAWN
Local Institution - 303, Tours
COMPLETED
Local Institution - 463, Verona
COMPLETED
Local Institution - 310, La Tronche
COMPLETED
Local Institution - 464, Bologna
COMPLETED
Local Institution - 345, Düsseldorf
RECRUITING
China Medical University Hospital, Taichung
COMPLETED
Local Institution - 346, Düsseldorf
COMPLETED
Local Institution - 680, Seville
COMPLETED
Local Institution - 479, Modena
COMPLETED
Local Institution - 462, Ferrara
ACTIVE_NOT_RECRUITING
Local Institution - 967, Cleveland
COMPLETED
Local Institution - 683, Valencia
COMPLETED
Local Institution - 961, Detroit
COMPLETED
Local Institution - 681, Barakaldo
COMPLETED
Local Institution - 305, Angers
COMPLETED
Local Institution - 423, Petah Tikva
ACTIVE_NOT_RECRUITING
Local Institution - 478, Florence
ACTIVE_NOT_RECRUITING
Local Institution - 471, Florence
RECRUITING
Chiang Mai University - Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
COMPLETED
Local Institution - 381, Thessaloniki
COMPLETED
Local Institution - 340, Mainz
COMPLETED
Local Institution - 306, Lille
RECRUITING
University Malaya Medical Centre, Kuala Lumpur
COMPLETED
Local Institution - 970, Chicago
COMPLETED
Local Institution - 308, Strasbourg
COMPLETED
Local Institution - 304, Pierre-Bénite
COMPLETED
Local Institution - 466, Brindisi
COMPLETED
Local Institution - 473, Lecce
COMPLETED
Local Institution - 302, Paris
WITHDRAWN
The University of Texas - MD Anderson Cancer Center, Houston
COMPLETED
Local Institution - 545, Johor Bahru
RECRUITING
AORN A Cardarelli, Napoli
RECRUITING
AOU dell'Universita degli Studi della Campania Luigi Vanvitelli, Napoli
COMPLETED
Local Institution - 347, München
RECRUITING
Queen Elizabeth Hospital, Kota Kinabalu
COMPLETED
Local Institution - 468, Reggio Calabria
COMPLETED
Local Institution - 422, Jerusalem
COMPLETED
Local Institution - 424, Jerusalem
RECRUITING
Hospital Umum Sarawak, Kuching
COMPLETED
Local Institution - 300, Créteil
COMPLETED
Local Institution - 978, Stanford
COMPLETED
Local Institution - 971, Oakland
COMPLETED
Local Institution - 761, Taipei
WITHDRAWN
Local Institution - 131, Beijing
WITHDRAWN
Local Institution - 132, Shanghai
WITHDRAWN
Local Institution - 130, Tianjin
WITHDRAWN
Local Institution - 133, Hangzhou
WITHDRAWN
Local Institution - 135, Guangzhou
WITHDRAWN
Local Institution - 134, Chengdu
RECRUITING
Rambam Health Corporation, Haifa
WITHDRAWN
Local Institution - 611, Nagasaki
RECRUITING
Childrens Hospital Los Angeles RHU, Los Angeles
COMPLETED
Local Institution - 973, Boston
WITHDRAWN
Vanderbilt - Ingram Cancer Center, Nashville
COMPLETED
Local Institution - 262, Toronto
COMPLETED
Local Institution - 260, Toronto
COMPLETED
Local Institution - 263, Toronto
COMPLETED
Local Institution - 348, Dresden
COMPLETED
Local Institution - 343, Halle
WITHDRAWN
Local Institution - 349, Leipzig
RECRUITING
Aghia Sophia' Children's General Hospital of Athens, Athens
RECRUITING
Laiko General Hospital of Athens - Center of Thalassemia, Athens
COMPLETED
Local Institution - 477, Cagliari
COMPLETED
Local Institution - 610, Nagoya
COMPLETED
Local Institution - 601, Kamogawa
RECRUITING
Matsuyama Red Cross Hospital, Matsuyama
RECRUITING
Ogaki Municipal Hospital, Ōgaki
RECRUITING
Japanese Red Cross Society Himeji Hospital, Himeji
ACTIVE_NOT_RECRUITING
Local Institution - 605, Hitachi
RECRUITING
Kitasato University Hospital, Sagamihara
WITHDRAWN
Local Institution - 0979, Sendai
RECRUITING
Tohoku University Hospital, Sendai
RECRUITING
Japanese Red Cross Medical Center, Shibuya City
RECRUITING
NTT Medical Center Tokyo, Shinagawa City
COMPLETED
Local Institution - 612, Chiba
RECRUITING
Shonan Kamakura General Hospital, Kamakura
RECRUITING
Osaka Metropolitan University Hospital, Osaka
ACTIVE_NOT_RECRUITING
Local Institution - 604, Osaka
RECRUITING
Chronic Care Center, Hazmiyeh
RECRUITING
Hospital Sultanah Bahiyah, Alor Star
COMPLETED
Local Institution - 580, Amsterdam
COMPLETED
Local Institution - 686, Barcelona
COMPLETED
Local Institution - 720, Gothenburg
COMPLETED
Local Institution - 722, Lund
COMPLETED
Local Institution - 721, Stockholm
RECRUITING
Acibadem Adana Hospital, Adana
COMPLETED
Local Institution - 885, Ankara
COMPLETED
Local Institution - 925, Aberdeen
WITHDRAWN
Local Institution - 921, Leeds
COMPLETED
Local Institution - 923, London
RECRUITING
Whittington Hospital, London
RECRUITING
University College London Hospitals NHS Foundation Trust - University College Hospital, London
COMPLETED
Local Institution - 928, London
COMPLETED
Local Institution - 924, London
WITHDRAWN
Local Institution - 929, Oxford
WITHDRAWN
Local Institution - 926, Sutton in Ashfield
Lead Sponsor
Celgene
INDUSTRY