First Line Therapy for High Risk Acute GVHD

PHASE2CompletedINTERVENTIONAL
Enrollment

198

Participants

Timeline

Start Date

August 25, 2019

Primary Completion Date

August 1, 2022

Study Completion Date

June 30, 2023

Conditions
aGVHDStem Cell Transplant Complications
Interventions
DRUG

Ruxolitinib

Participants began oral administration of ruxolitinib at 5 mg QD;Methylprednisolone: 1mg/kg/d , iv or iv gtt for at least 5 days, then taper according to the clinical response.

DRUG

Corticosteroid

Methylprednisolone: 2mg/kg/d , iv or iv gtt for at least 3 days, then taper according to the clinical response. 1mg/kg/d , iv or iv gtt for at least 5 days, then taper according to the clinical response.

Trial Locations (1)

100853

Chinese PLA General Hospital, Beijing

All Listed Sponsors
collaborator

LU DAOPEI MEDICAL

UNKNOWN

collaborator

960th Hospital of PLA

UNKNOWN

collaborator

The Second Hospital of Hebei Medical University

OTHER

collaborator

The Second Affiliated Hospital of Dalian Medical University

OTHER

collaborator

Air Force Military Medical University, China

OTHER

lead

Chinese PLA General Hospital

OTHER

NCT04061876 - First Line Therapy for High Risk Acute GVHD | Biotech Hunter | Biotech Hunter