Rituximab and Ibrutinib (RI) Versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as Initial Therapy for Waldenström's Macroglobulinaemia

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

148

Participants

Timeline

Start Date

February 3, 2020

Primary Completion Date

March 31, 2030

Study Completion Date

March 31, 2030

Conditions
Waldenstrom Macroglobulinemia
Interventions
DRUG

Dexamethasone, cyclophosphamide, rituximab

DRC Arm (chemotherapy) consists of dexamethasone, cyclophosphamide and rituximab treatment

DRUG

Rituximab, ibrutinib

RI Arm (chemotherapy free) consists of rituximab and ibrutinib treatment

Trial Locations (25)

Unknown

RECRUITING

Royal United Hospital, Bath, Bath

RECRUITING

The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth

RECRUITING

East Kent Hospitals University NHS Foundation Trust, Canterbury

RECRUITING

University Hospital of Wales, Cardiff

RECRUITING

Colchester Hospital, Colchester

RECRUITING

Mid Yorkshire NHS Trust, Dewsbury

RECRUITING

Royal Devon University Hospital, Exeter

RECRUITING

Medway Maritime Hospital, Gillingham

RECRUITING

Castle Hill Hospital, Hull

RECRUITING

NHS Lanarkshire, Lanark

RECRUITING

St James's University Hospital, Leeds

RECRUITING

Leicester Royal Infirmary, Leicester

RECRUITING

Barking, Havering and Redbridge University Hospitals NHS Trust, London

RECRUITING

Barts Health NHS Trust, London

RECRUITING

King's College Hospital, London

RECRUITING

Northwick Park Hospital, London

RECRUITING

University College London Hospitals NHS Foundation Trust, London

RECRUITING

Christie NHS Foundation Trust, Manchester

RECRUITING

Norfolk and Norwich Hospital, Norwich

RECRUITING

Oxford University Hospital, Oxford

RECRUITING

University Hospitals Plymouth NHS Trust, Plymouth

RECRUITING

Salisbury NHS Foundation Trust, Salisbury

RECRUITING

Torbay & Newton Abbot Hospital, Torquay

RECRUITING

Royal Cornwall Hospital, Truro

RECRUITING

Hampshire Hospitals NHS Foundation Trust, Winchester

All Listed Sponsors
collaborator

Janssen-Cilag Ltd.

INDUSTRY

lead

University College, London

OTHER