Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations

PHASE3CompletedINTERVENTIONAL
Enrollment

689

Participants

Timeline

Start Date

August 26, 2019

Primary Completion Date

July 28, 2025

Study Completion Date

July 28, 2025

Conditions
Chronic Obstructive Pulmonary Disease
Interventions
BIOLOGICAL

Benralizumab

Benralizumab solution for injection in accessorized prefilled syringe (APFS) will be administered subcutaneously (SC) every 4 weeks for the first 3 doses - Weeks 0, 4 and 8, and then every 8 weeks until the end of treatment.

BIOLOGICAL

Placebo

Matching placebo will be administered subcutaneously with accessorized prefilled syringe (APFS) every 4 weeks for the first 3 doses - Weeks 0, 4 and 8, and then every 8 weeks until the end of treatment.

Trial Locations (343)

1033

Research Site, Budapest

1051

Research Site, Auckland

1100

Research Site, Quezon City

1425

Research Site, Ciudad de Buenos Aires

1888

Research Site, San Juan Bautista

2045

Research Site, Törökbálint

2100

Research Site, Gödöllő

2229

Research Site, Caringbah

2400

Research Site, København NV

2440

Research Site, Százhalombatta

2650

Research Site, Edegem

Research Site, Hvidovre

2660

Research Site, Balassagyarmat

2900

Research Site, Komárom

3004

Research Site, Melbourne

3019

Research Site, Marilao

3204

Research Site, Hamilton

3320

Research Site, Kozloduy

3780

Research Site, Edelény

3860

Research Site, Encs

4000

Research Site, San Miguel de Tucumán

Research Site, Roskilde

4020

Research Site, Linz

4030

Research Site, Los Baños

4080

Research Site, Hajdúnánás

4101

Research Site, South Brisbane

4215

Research Site, Southport

4600

Research Site, Thalheim

4710

Research Site, Grieskirchen

4820

Research Site, Bad Ischl

5000

Research Site, Odense C

Research Site, Iloilo City

5101

Research Site, Erpent

6003

Research Site, Stara Zagora

6163

Research Site, Spearwood

6700

Research Site, Bludenz

6722

Research Site, Szeged

7002

Research Site, Rousse

7100

Research Site, Vejle

7635

Research Site, Pécs

8024

Research Site, Christchurch

8600

Research Site, Siófok

9000

Research Site, Aalborg

9016

Research Site, Dunedin

10050

Research Site, Hohhot

10461

Research Site, The Bronx

10717

Research Site, Berlin

11527

Research Site, Athens

12157

Research Site, Berlin

12553

Research Site, New Windsor

13187

Research Site, Berlin

14010

Research Site, Baotou

14215

Research Site, Buffalo

14467

Research Site, Potsdam

15213

Research Site, Pittsburgh

15478

Research Site, Smithfield

15801

Research Site, DuBois

16132

Research Site, Genoa

19140

Research Site, Philadelphia

20089

Research Site, Rozzano

20142

Research Site, Milan

20157

Research Site, Milan

20354

Research Site, Hamburg

21044

Research Site, Columbia

21224

Research Site, Baltimore

23188

Research Site, Williamsburg

24153

Research Site, Salem

24210

Research Site, Abingdon

26426

Research Site, Wŏnju

26505

Research Site, Morgantown

27103

Research Site, Winston-Salem

27215

Research Site, Burlington

27909

Research Site, Elizabeth City

28007

Research Site, Madrid

28046

Research Site, Madrid

28054

Research Site, Gastonia

28117

Research Site, Mooresville

28277

Research Site, Charlotte

28401

Research Site, Wilmington

28562

Research Site, New Bern

28850

Research Site, Madrid

29010

Research Site, Málaga

29406

Research Site, North Charleston

29464

Research Site, Mt. Pleasant

29732

Research Site, Rock Hill

30046

Research Site, Lawrenceville

31224

Research Site, Peine

31326

Research Site, Rincon

32117

Research Site, Daytona Beach

32132

Research Site, Edgewater

32204

Research Site, Jacksonville

32209

Research Site, Jacksonville

32503

Research Site, Pensacola

32789

Research Site, Winter Park

32819

Research Site, Orlando

33125

Research Site, Miami

33343

Research Site, Mersin

33607

Research Site, Tampa

33707

Research Site, St. Petersburg

33765

Research Site, Clearwater

34098

Research Site, Istanbul

34741

Research Site, Kissimmee

34746

Research Site, Kissimmee

34748

Research Site, Leesburg

34844

Research Site, Istanbul

35037

Research Site, Marburg

35110

Research Site, Izmir

37067

Research Site, Franklin

37075

Research Site, Hendersonville

37404

Research Site, Chattanooga

37601

Research Site, Johnson City

39008

Research Site, Santander

39770

Research Site, Laredo

40324

Research Site, Georgetown

41380

Research Site, Kocaeli

42123

Research Site, Reggio Emilia

42415

Research Site, Daegu

43215

Research Site, Columbus

44100

Research Site, Guadalajara

44106

Research Site, Cleveland

44124

Research Site, Cona

44130

Research Site, Guadalajara

44200

Research Site, Guadalajara

45500

Research Site, Ioannina

46360

Research Site, Michigan City

48231

Research Site, Warendorf

48336

Research Site, Farmington Hills

48431

Research Site, Rheine

51069

Research Site, Cologne

52242

Research Site, Iowa City

53110

Research Site, Cudahy

54907

Research Site, Jeonju

56068

Research Site, Koblenz

56429

Research Site, Thessaloniki

57010

Research Site, Exohi Thessaloniki

Research Site, Thessaloniki

57702

Research Site, Rapid City

60611

Research Site, Chicago

61636

Research Site, Peoria

62269

Research Site, O'Fallon

63263

Research Site, Neu-Isenburg

64283

Research Site, Darmstadt

66160

Research Site, Kansas City

68124

Research Site, Omaha

68510

Research Site, Lincoln

72209

Research Site, Little Rock

73106

Research Site, Oklahoma City

75390

Research Site, Dallas

76104

Research Site, Fort Worth

77079

Research Site, Houston

77375

Research Site, Tomball

77429

Research Site, Cypress

78028

Research Site, Kerrville

78258

Research Site, San Antonio

79106

Research Site, Amarillo

79124

Research Site, Amarillo

80007

Research Site, Barranquilla

80131

Research Site, Napoli

84102

Research Site, Salt Lake City

85374

Research Site, Surprise

90033

Research Site, Los Angeles

90048

Research Site, Los Angeles

91324

Research Site, Northridge

91910

Research Site, Veracruz

92262

Research Site, Palm Springs

92663

Research Site, Newport Beach

92683

Research Site, Westminster

96049

Research Site, Bamberg

97070

Research Site, Mérida

97504

Research Site, Medford

98208

Research Site, Everett

99204

Research Site, Spokane

100000

Research Site, Hanoi

100034

Research Site, Beijing

102218

Research Site, Beijing

200002

Research Site, Shanghai

200032

Research Site, Shanghai

200251

Research Site, Zipaquirá

200433

Research Site, Shanghai

215000

Research Site, Suzhou

230001

Research Site, Hefei

302039

Research Site, Jaipur

317000

Research Site, Linhai

325027

Research Site, Wenzhou

330006

Research Site, Nanchang

341099

Research Site, Ganzhou

401107

Research Site, Thāne

402260

Research Site, Chongqing

410005

Research Site, Changsha

410015

Research Site, Changsha

430022

Research Site, Wuhan

430030

Research Site, Wuhan

430033

Research Site, Changsha

450003

Research Site, Zhengzhou

500038

Research Site, Hyderabad

510180

Research Site, Guangzhou

518020

Research Site, Shenzhen

522001

Research Site, Guntur

524001

Research Site, Zhanjiang

550002

Research Site, Guiyang

570311

Research Site, Haikou

610041

Research Site, Chengdu

641028

Research Site, Coimbatore

660003

Research Site, Pereira

681004

Research Site, Floridablanca

700000

Research Site, Ho Chi Minh City

Research Site, Hồ Chí Minh

710061

Research Site, Xi'an

750001

Research Site, Yinchuan

830054

Research Site, Ürümqi

2260000

Research Site, Quillota

3341643

Research Site, Curicó

3465584

Research Site, Talca

5001000

Research Site, Medellín

7500571

Research Site, Santiago

7500698

Research Site, Santiago

7770484

Research Site, Chile

8380453

Research Site, Santiago

76001000

Research Site, Santiago de Cali

06902

Research Site, Stamford

02215

Research Site, Boston

02747

Research Site, North Dartmouth

08755

Research Site, Toms River

S2000PBJ

Research Site, Buenos Aires

C1012AAR

Research Site, CABA

C1440BRR

Research Site, Ciudad Autónoma de Buenos Aire

X5003DCE

Research Site, Córdoba

B1602DQD

Research Site, Florida

B7600GWV

Research Site, Mar del Plata

M5500CCG

Research Site, Mendoza

B1646EBJ

Research Site, San Fernando

A-8330

Research Site, Feldbach

89030-101

Research Site, Blumenau

18.618-686

Research Site, Botucatu

88036-800

Research Site, Florianópolis

87015-000

Research Site, Maringá

9002-060

Research Site, Porto Alegre

90020-090

Research Site, Porto Alegre

90610-000

Research Site, Porto Alegre

91350-200

Research Site, Porto Alegre

09080-110

Research Site, Santo André

09750-420

Research Site, São Bernardo do Campo

05403-000

Research Site, São Paulo

18040-425

Research Site, Sorocaba

T3B 0M3

Research Site, Calgary

A1A 3R5

Research Site, St. John's

L1S 2J5

Research Site, Ajax

L4M 6M2

Research Site, Barrie

N7T 4X3

Research Site, Sarnia

L4A 1H2

Research Site, Stouffville

M5T 3A9

Research Site, Toronto

M9V 4B4

Research Site, Toronto

H4A 3J1

Research Site, Montreal

G1V 4W2

Research Site, Québec

G1W 4R4

Research Site, Québec

G2J 0C4

Research Site, Québec

S7N 0W8

Research Site, Saskatoon

G7H 5H6

Research Site, Chicoutimi

Unknown

Research Site, Hebei

010017

Research Site, Hohhot

250 01

Research Site, Brandýs nad Labem

377 01

Research Site, Jindřichův Hradec

708 68

Research Site, Ostrava

337 22

Research Site, Rokycany

415 01

Research Site, Teplice

D-30173

Research Site, Hanover

04103

Research Site, Leipzig

04207

Research Site, Leipzig

04357

Research Site, Leipzig

673 008

Research Site, Calicut

520 008

Research Site, Vijayawada

00168

Research Site, Roma

103-0022

Research Site, Chūōku

104-0031

Research Site, Chūōku

814-0180

Research Site, Fukuoka

672-8064

Research Site, Himeji-shi

312-0057

Research Site, Hitachi-Naka

610-0113

Research Site, Joyo-shi

586-8521

Research Site, Kawachinagano-shi

596-8501

Research Site, Kishiwada-shi

650-0047

Research Site, Kobe

136-0075

Research Site, Kōtoku

737-0023

Research Site, Kure-shi

515-8544

Research Site, Matsusaka-shi

509-6134

Research Site, Mizunami-shi

940-2085

Research Site, Nagaoka-shi

457-8511

Research Site, Nagoya

663-8501

Research Site, Nishinomiya-shi

700-8558

Research Site, Okayama

531-0073

Research Site, Osaka

252-0315

Research Site, Sagamihara-shi

762-8550

Research Site, Sakaide-shi

591-8555

Research Site, Sakaishi

489-8642

Research Site, Seto-shi

140-8522

Research Site, Shinagawa-ku

142-8666

Research Site, Shinagawa-ku

170-0002

Research Site, Toshima-ku

170-0003

Research Site, Toshima-ku

171-0014

Research Site, Toshima-ku

560-8552

Research Site, Toyonaka-shi

386-8610

Research Site, Ueda-shi

832-0059

Research Site, Yanagawa-shi

223-0059

Research Site, Yokohama

4818 CK

Research Site, Breda

8934 AD

Research Site, Leeuwarden

0626

Research Site, Auckland

15-044

Research Site, Bialystok

26-060

Research Site, Chęciny

05-825

Research Site, Grodzisk Mazowiecki

40-648

Research Site, Katowice

90-153

Research Site, Lodz

27-400

Research Site, Ostrowiec Świętokrzyski

60-693

Research Site, Poznan

61-578

Research Site, Poznan

32-100

Research Site, Proszowice

35-051

Research Site, Rzeszów

02-793

Research Site, Warsaw

98-300

Research Site, Wieluń

03312

Research Site, Seoul

04401

Research Site, Seoul

05030

Research Site, Seoul

06591

Research Site, Seoul

08017

Research Site, Barcelona

08907

Research Site, Hospitalet de Llobregat(Barcel

413 46

Research Site, Gothenburg

413 45

Research Site, Göteborg

222 22

Research Site, Lund

205 02

Research Site, Malmo

114 46

Research Site, Stockholm

01330

Research Site, Adana

S75 3DL

Research Site, Barnsley

B9 5SS

Research Site, Birmingham

FY2 0JH

Research Site, Blackpool

BD9 6RJ

Research Site, Bradford

KT16 0PZ

Research Site, Chertsey

HU16 5JQ

Research Site, Cottingham

LE3 9QP

Research Site, Leicester

M13 9NQ

Research Site, Manchester

OX3 7LE

Research Site, Oxford

PH1 1NX

Research Site, Perth

SO166YD

Research Site, Southampton

TS17 6EW

Research Site, Stockton-on-Tees

ML2 0DP

Research Site, Wishaw

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY