DFS and QOL After Modified Radical Mastectomy vs. Expanded Mckissock Surgery for EIC of the Breast

NARecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

October 1, 2019

Primary Completion Date

September 1, 2025

Study Completion Date

September 1, 2026

Conditions
Breast Neoplasms
Interventions
PROCEDURE

Expanded Mckissock surgery

Expanded Mckissock surgery: (1) According to patient's preoperative imaging results and subjective expectations of their own breast morphology, the incision design and breast surface marking will be performed under the standing position. (2) After general anesthesia, the upper limbs will be abducted, and the upper body will be tilted by 15°-20° to dermatize the labeled skin around and below the areola. (3) The medial and lateral flaps will be dissociated to remove the total gland with nipple and areola preserved. (4) The cutting-edge of nipple-areola complex will be sent for cancer screening. The axillary lymph node biopsy or cleaning will be performed along the outer edge of the pectoralis major muscle. (5) The vertical subcutaneous pedicle flaps will be W-folded, and the flaps on both sides will be pulled to the vertical pedicle to reshape the breast. During this process, the breast and armpit drainage tubes will be indwelled.

PROCEDURE

Modified radical mastectomy

The patients will be placed in the supine position. After intravenous anesthesia, the tumor boundary will be marked and the breast will be removed. The vertical subcutaneous pedicle flaps will be W-folded, and the flaps on both sides will be pulled to the vertical pedicle to reshape the breast. During this process, the breast and armpit drainage tubes will be indwelled.

Trial Locations (3)

110004

RECRUITING

Shengjing Hospital of China Medical University, Shenyang

110042

RECRUITING

Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shengyang

117000

RECRUITING

General Hospital of Benxi Iron & Steel Industry Group of Liaoning Health Industry Group, Benxi

All Listed Sponsors
lead

Shengjing Hospital

OTHER