100
Participants
Start Date
September 12, 2019
Primary Completion Date
January 7, 2020
Study Completion Date
January 7, 2020
Pyronaridine Tetraphosphate/Artesunate
Adults: Tablets containing 180 mg pyronaridine-tetraphosphate/60mg artesunate (Pyramax, Shin Poong Pharmaceutical Co.), administered according to weight. Children: Granules containing 60 mg pyronaridine-tetraphosphate/20mg artesunate, administered according to weight.
Dihydroartemisinin/Piperaquine
Tablets containing 40 mg dihydroartemisinin/320 mg piperaquine tablets (Eurartesim, Sigma Tau), administered according to weight.
Primaquine Diphosphate
Extemporaneous preparation of 1mg/mL primaquine phosphate solution, from tablets containing 30mg primaquine (A-PQ 30®, ACE pharmaceuticals, NL) dissolved in 30mL water with a non-interacting fruit-flavoured syrup. Solution will be given at 0.25mg/kg.
Malaria Research and Training Centre, Bamako
Radboud university medical center, Nijmegen
Malaria Research and Training Center, Bamako, Mali
OTHER
Radboud University Medical Center
OTHER
London School of Hygiene and Tropical Medicine
OTHER