Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

PHASE3RecruitingINTERVENTIONAL
Enrollment

3,200

Participants

Timeline

Start Date

December 13, 2019

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
Atrial FibrillationStrokeBleeding
Interventions
DRUG

Antiplatelet-only strategy

Aspirin 75-325 mg once-daily or a P2Y12-inhibitor (clopidogrel or ticagrelor)

DRUG

Oral Anticoagulant plus background antiplatelet therapy

OAC with vitamin K antagonist (VKA) with international normalized ratio (INR) target 2-3 or any approved direct oral anticoagulant OR apixaban, rivaroxaban, edoxaban or dabigatran) in addition to background antiplatelet therapy with aspirin 75-325mg once-daily or a P2Y12-inhibitor (clopidogrel or ticagrelor)

Trial Locations (96)

10029

NOT_YET_RECRUITING

The Mount Sinai Hospital, New York

10032

RECRUITING

Columbia University Medical Center, New York

10467

RECRUITING

Montefiore Medical Center, The Bronx

11023

RECRUITING

Northwell Health System, Great Neck

11353

NOT_YET_RECRUITING

University Heart Center Hamburg, Berlin

13347

RECRUITING

Heart Center Leipzig, Berlin

15212

RECRUITING

Allegheny Health Network, Pittsburgh

16148

WITHDRAWN

University of Pittsburgh Medical Center, Hermitage

19104

RECRUITING

University of Pennsylvania, Philadelphia

20010

RECRUITING

MedStar Washington Hospital Center, Washington D.C.

20814

RECRUITING

Suburban Hospital, Bethesda

21201

RECRUITING

University of Maryland, Baltimore

21287

RECRUITING

Johns Hopkins, Baltimore

22042

ACTIVE_NOT_RECRUITING

Inova Health, Falls Church

22908

RECRUITING

University of Virginia Health System, Charlottesville

26506

RECRUITING

West Virginia University, Morgantown

27610

WITHDRAWN

WakeMed, Raleigh

27710

RECRUITING

Duke University, Durham

27858

RECRUITING

East Carolina University, Greenville

30308

RECRUITING

Emory University, Atlanta

30309

RECRUITING

Piedmont Healthcare Inc., Atlanta

43210

RECRUITING

Ohio State University Medical Center, Columbus

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

46202

RECRUITING

Indiana University, Indianapolis

46260

RECRUITING

Ascension St. Vincent, Indianapolis

46825

RECRUITING

Lutheran Medical Center, Fort Wayne

48109

RECRUITING

University of Michigan, Ann Arbor

53792

ACTIVE_NOT_RECRUITING

University of Wisconsin, Madison

55905

NOT_YET_RECRUITING

Mayo Clinic, Rochester

63110

RECRUITING

Washington University School of Medicine, St Louis

64111

RECRUITING

Mid America Health Institute, Kansas City

70121

RECRUITING

Ochsner Clinic, New Orleans

72205

RECRUITING

CHI St. Vincent, Arkansas, Little Rock

74103

RECRUITING

Ascension St. John, Tulsa

75093

RECRUITING

Baylor Research Institute, Plano

77030

RECRUITING

Baylor College of Medicine, Houston

80012

ACTIVE_NOT_RECRUITING

Medical Center of Aurora, Aurora

84107

RECRUITING

Intermountain CV Research, Murray

84112

RECRUITING

University of Utah, Salt Lake City

90033

RECRUITING

University of Southern California, Los Angeles

90048

RECRUITING

Cedars-Sinai Medical Center, Los Angeles

94305

RECRUITING

Stanford University, Stanford

06810

ACTIVE_NOT_RECRUITING

Western Connecticut Hospital Systems, Danbury

06520-8039

RECRUITING

Yale Medicine, New Haven

04102

RECRUITING

Maine Medical Center, Portland

02114

RECRUITING

Massachusetts General Hospital, Boston

02115

RECRUITING

Brigham and Women's Hospital, Boston

02118

RECRUITING

Boston Medical Center, Boston

01199

ACTIVE_NOT_RECRUITING

Baystate Health, Springfield

03766

RECRUITING

Dartmouth-Hitchcock Medical Center, Lebanon

07753

RECRUITING

Jersey Shore University Medical Center, Neptune City

05401

RECRUITING

University of Vermont, Burlington

T6G2B7

RECRUITING

University of Alberta Hospital, Edmonton

N6A 5A5

RECRUITING

London Health Sciences Centre, London

M4N 3M5

RECRUITING

Sunnybrook Hospital, Toronto

H1T 1C8

RECRUITING

Montreal Heart Institute, Montreal

H2W 1T8

RECRUITING

Centre Hospitalier de l'Université de Montréal, Montreal

H4J 1C5

WITHDRAWN

Hôpital du Sacré-Cœur de Montréal, Montreal

G1V 4G5

RECRUITING

Hôpital Laval, Québec

Unknown

NOT_YET_RECRUITING

University of Ottawa Heart Institute, Ottawa

NOT_YET_RECRUITING

Toronto General Hospital, Toronto

NOT_YET_RECRUITING

University Medical Center Göttingen, Göttingen

RECRUITING

University Medical Center Jena, Jena

NOT_YET_RECRUITING

Clinic Bad Neustadt - Medical Center for Heart and Vascular Diseases, Bad Neustadt an der Saale

NOT_YET_RECRUITING

HDZ-NRW Bad Oeynhausen, Bad Oeynhausen

NOT_YET_RECRUITING

Charité Berlin - Benjamin Franklin Campus, Berlin

NOT_YET_RECRUITING

Charité Berlin - Rudolf Virchow Campus, Berlin

RECRUITING

German Heart Center Berlin, Berlin

RECRUITING

University Hospital Bonn, Bonn

NOT_YET_RECRUITING

Medical Center Braunschweig, Braunschweig

RECRUITING

Heinrich Heine University Düsseldorf, Düsseldorf

RECRUITING

Frankfurt University Hospital, Frankfurt

NOT_YET_RECRUITING

University Medical Center Frankfurt, Frankfurt

NOT_YET_RECRUITING

Heart Center, University of Freiburg, Freiburg im Breisgau

NOT_YET_RECRUITING

University Medical Center Heidelberg, Heidelberg

NOT_YET_RECRUITING

University Medical Center Schleswig-Holstein Kiel, Kiel

NOT_YET_RECRUITING

University Medical Center Schleswig-Holstein Lübeck, Lübeck

RECRUITING

University Hospital Magdeburg, Magdeburg

NOT_YET_RECRUITING

German Heart Center Munich, Munich

NOT_YET_RECRUITING

Medical Center of the Ludwig-Maximilians-University Munich, Munich

RECRUITING

Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool

RECRUITING

Barts Health NHS Trust, London

RECRUITING

Imperial College Healthcare NHS Trust, London

RECRUITING

Royal Wolverhampton NHS Trust, Wolverhampton

RECRUITING

Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool

RECRUITING

Royal Papworth Hospital NHS Foundation Trust, Cambridge

RECRUITING

University Hospitals of Leicester NHS Trust, Leicester

RECRUITING

South Tees Hospitals NHS Foundation Trust, Middlesbrough

RECRUITING

Nottingham University Hospitals NHS Trust, Nottingham

RECRUITING

University Hospitals Plymouth NHS Trust, Plymouth

RECRUITING

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield

RECRUITING

University Hospital Southampton NHS Foundation Trust, Southampton

BS1 3NU

RECRUITING

University Hospitals Bristol NHS Foundation Trust, Bristol

HU16 5JQ

RECRUITING

Hull University Teaching Hospitals NHS Trust, Cottingham

OX3 9DU

RECRUITING

Oxford University Hospitals NHS Foundation Trust, Oxford

BN11 2DH

RECRUITING

University Hospitals Sussex NHS Foundation Trust, Worthing

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Vanderbilt University Medical Center

OTHER

lead

Icahn School of Medicine at Mount Sinai

OTHER