Improving Dosing of Vancomycin in Young Infants With Infections

PHASE4CompletedINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

August 30, 2019

Primary Completion Date

December 29, 2020

Study Completion Date

January 3, 2021

Conditions
SepsisInfectionBacteremia
Interventions
DRUG

Vancomycin - model-based dosing regimen

A dosing calculator based on a population pharmacokinetic model for vancomycin will be used to generate a participant's intermittent vancomycin dosing regimen. The participant's post-menstrual age, weight, creatinine and the target trough vancomycin level will be entered into the dosing calculator and the dose will be generated (intermittent infusion, dosing frequency will be from 1 to 4 times per day according to the corrected gestational age).

Trial Locations (4)

2031

Royal Hospital for Women, Sydney

3052

Royal Children's Hospital Melbourne, Melbourne

Unknown

Children's Hospital at Westmead, Sydney

Monash Children's Hospital, Melbourne

Sponsors
All Listed Sponsors
collaborator

Royal Children's Hospital

OTHER

collaborator

Royal Hospital For Women

OTHER

collaborator

University of Otago

OTHER

collaborator

Sydney Children's Hospitals Network

OTHER

collaborator

Monash Health

OTHER

lead

Murdoch Childrens Research Institute

OTHER