A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia

PHASE3CompletedINTERVENTIONAL
Enrollment

4,392

Participants

Timeline

Start Date

August 19, 2019

Primary Completion Date

April 5, 2024

Study Completion Date

April 5, 2024

Conditions
Pneumonia
Interventions
DRUG

Benzyl penicillin

Benzyl penicillin is a penicillin antibiotic.

DRUG

Gentamicin Sulfate

Gentamicin is an aminoglycoside antibiotic.

DRUG

Ceftriaxone

Ceftriaxone is a third generation cephalosporin antibiotic active against a wide range of gram negative and positive bacteria.

DRUG

Amoxicillin Clavulanate

Amoxicillin Clavulanate is a combination of amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor.

OTHER

Intravenous fluid

Maintenance fluids administered for at least 24 hours.

OTHER

Nasogastric feeds

Feeds given via nasogastric tube. Feeds may include cow's milk, breast milk, porridge, formula among others.

DRUG

Ampicillin

Ampicillin is a penicillin-type antibiotic.

Trial Locations (1)

Unknown

Machakos Level 5 Hospital, Machakos

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Nairobi

OTHER

collaborator

London School of Hygiene and Tropical Medicine

OTHER

collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

collaborator

Department for International Development, United Kingdom

OTHER_GOV

collaborator

Medical Research Council

OTHER_GOV

collaborator

Wellcome Trust

OTHER

collaborator

Kenya Ministry of Health

OTHER_GOV

lead

University of Oxford

OTHER