Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

115

Participants

Timeline

Start Date

October 21, 2019

Primary Completion Date

October 30, 2026

Study Completion Date

October 30, 2026

Conditions
Solid Tumor, Adult
Interventions
BIOLOGICAL

GAd-209-FSP low dose

GAd20-209-FSP IP, low dose

BIOLOGICAL

MVA-209-FSP low dose

MVA-209-FSP IP, low dose

BIOLOGICAL

GAd-209-FSP high dose

GAd20-209-FSP IP, high dose

BIOLOGICAL

MVA-209-FSP high dose

MVA-209-FSP IP, high dose

BIOLOGICAL

GAd20-209-FSP, RP2D

GAd20-209-FSP IP, RP2D

BIOLOGICAL

MVA-209-FSP, RP2D

MVA-209-FSP IP, RP2D

DRUG

KEYTRUDA®

anti-PD-1 checkpoint inhibitor (200 mg; Q3W)

Trial Locations (46)

1200

Cliniques Universitaires Saint-Luc - Centre du Cancer, Brussels

4000

CHU de Liège, Liège

6800

Centre Hospitalier de l'Ardenne - Libramont - Clinique du Sein, Libramont

10016

NYU Langone Medical Center, New York

10021

Weill Cornell Medicine / New York-Presbyterian Hospital, New York

10060

Candiolo cancer Center,FPO IRCCS, Candiolo

14004

Hospital Universitario Reina Sofia, Córdoba

14203

Roswell Park Comprehensive Cancer Center, Buffalo

15006

Hospital Universitario de A Coruna, A Coruña

15706

Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela

18014

Hospital Universitario Virgen de las Nieves, Granada

20132

IRCCS Ospedale San Raffaele, Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20162

Ospedale Niguarda, Milan

21287

Johns Hopkins University, Baltimore

28007

Hospital General Universitario Gregorio Marañón, Madrid

28027

Clinica Universidad de Navarra, Madrid

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

31008

Clinica Universidad de Navarra, Pamplona

33140

Mt. Sinai, Miami Beach

33322

Boca Raton Clinical Research, Plantation

37007

Complejo Asistencial de Salamanca, Salamanca

46014

Hospital General Universitario de Valencia, Valencia

46526

Goshen Center for Cancer Care, Goshen

50009

Hospital Universitario Miguel Servet, Zaragoza

53100

AOUS Policlinico Le Scotte, Siena

63110

Washington University School of Medicine, Division of Oncology, St Louis

77030

MD Anderson Cancer Center (MDACC), Houston

83100

Aorn Sg Moscati, Avellino

90089

USC Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

92618

City of Hope Comprehensive Cancer Center, Irvine

92663

USC Norris Comprehensive Cancer Center, Newport Beach

M5G 2M9

Mount Sinai Hospital, Toronto

Princess Margaret Cancer Center, Toronto

08003

Hospital Del Mar, Barcelona

08028

Hospital Universitari Dexeus, Barcelona

08035

Hospital Vall d'Hebron, Barcelona

08908

Institut Catala d'Oncologia Hospitalet, Barcelona

Unknown

Hospital Clinic de Barcelona, Barcelona

Hospital Universitario HM Sanchinarro, Madrid

Hospital Universitario Marques de Valdecilla, Santander

University Clinical Hospital Valencia, Valencia

University College London Hospitals NHS Foundation Trust Cancer Clinical Trials Unit, London

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Nouscom SRL

INDUSTRY

NCT04041310 - Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors | Biotech Hunter | Biotech Hunter