A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

732

Participants

Timeline

Start Date

September 30, 2019

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2026

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Nivolumab

Participants will receive nivolumab as intravenous (IV) infusion.

DRUG

Ipilimumab

Participants will receive ipilimumab as IV infusion.

DRUG

Sorafenib

Participants will receive sorafenib as oral tablets.

DRUG

lenvatinib

Participants will receive lenvatinib as oral capsules.

Trial Locations (210)

0

Local Institution - 0095, Santiago

333

Local Institution - 0173, Taoyuan District

704

Local Institution - 0168, Tainan City

736

Local Institution - 0270, Tainan City

807

Local Institution - 0272, Kaohsiung City

1023

Local Institution - 0047, Auckland

1070

Local Institution - 0034, Brussels

1090

Local Institution - 0186, Vienna

1871

Local Institution - 0038, Liverpool

2000

Local Institution - 0282, Rosario

2145

Local Institution - 0002, Westmead

2217

Local Institution - 0003, Kogarah

2700

Local Institution - 0057, Wiener Neustadt

3000

Local Institution - 0064, Leuven

3004

Local Institution - 0001, Melbourne

3010

Local Institution - 0063, Bern

3021

Local Institution - 0020, St Albans

3065

Local Institution - 0026, Fitzroy

3100

Local Institution - 0114, Sankt Pölten

3168

Local Institution - 0019, Clayton

4000

Local Institution - 0058, San Miguel de Tucumán

Local Institution - 0104, Liège

4029

Local Institution - 0013, Herston

4560

Local Institution - 0004, Birtinya

5000

Local Institution - 0009, Adelaide

6202

Local Institution - 0067, Nice

7100

Local Institution - 0099, Haine-Saint-Paul

8011

Local Institution - 0286, Christchurch

8036

Local Institution - 0188, Graz

8308

Local Institution - 0167, Guro-gu

9000

Local Institution - 0124, Ghent

Local Institution - 0298, Ghent

9020

Local Institution - 0065, Klagenfurt

10002

Local Institution - 0144, Taipei

10060

Local Institution - 0084, Candiolo

11266

Local Institution - 0078, Taipei

13009

Local Institution, Marseille

13496

Local Institution - 0143, Seongnam-si

14004

Local Institution - 0090, Córdoba

14033

Local Institution - 0116, Caen

14059

Local Institution - 0274, Prague

15212

Local Institution - 0284, Pittsburgh

20007

Local Institution - 0077, Washington D.C.

20089

Local Institution - 0101, Rozzano

20122

Local Institution - 0039, Milan

20246

Local Institution - 0006, Hamburg

21000

Local Institution - 0138, Dijon

21287

Local Institution - 0190, Baltimore

28007

Local Institution - 0041, Madrid

28028

Local Institution - 0093, Madrid

28035

Local Institution - 0290, Madrid

28100

Local Institution - 0100, Novara

28222

Local Institution - 0045, Majadahonda

30120

Local Institution - 0087, El Palmar

30625

Local Institution - 0102, Hanover

31008

Local Institution - 0085, Pamplona

31059

Local Institution - 0042, Toulouse

33604

Local Institution - 0025, Pessac

34295

Local Institution - 0082, Montpellier

35128

Local Institution - 0219, Padua

36100

Local Institution - 0044, Vicenza

38043

Local Institution - 0081, Grenoble

39008

Local Institution - 0088, Santander

40217

Local Institution - 0027, Louisville

40447

Local Institution - 0105, Taichung

40705

Local Institution - 0271, Taichung

43126

Local Institution - 0033, Parma

43623

Local Institution - 0043, Toledo

45136

Local Institution - 0053, North Rhine-Westphalia

45147

Local Institution - 0052, Essen

47014

Local Institution - 0110, Meldola

48105

Local Institution, Ann Arbor

48202

Local Institution - 0018, Detroit

49241

Local Institution - 0142, Busan

50009

Local Institution - 0040, Zaragoza

50937

Local Institution - 0028, Cologne

53100

Local Institution - 0111, Siena

53127

Local Institution - 0231, Bonn

54500

Local Institution - 0071, Vandœuvre-lès-Nancy

55131

Local Institution - 0031, Mainz

60200

Local Institution, Brno

60590

Local Institution - 0005, Frankfurt am Main

68167

Local Institution - 0056, Mannheim

69004

Local Institution - 0070, Lyon

75203

Local Institution - 0304, Dallas

77030

Local Institution - 0202, Houston

79106

Local Institution - 0185, Freiburg im Breisgau

79410

Local Institution - 0046, Lubbock

80054

Local Institution - 0068, Amiens

80219

Local Institution - 0148, Gdansk

81675

Local Institution, München

83301

Local Institution - 0096, Kaohsiung City

84106

Local Institution - 0172, Salt Lake City

85719

Local Institution - 0292, Tucson

86021

Local Institution - 0137, Poitiers

92110

Local Institution - 0069, Clichy

92118

Local Institution - 0288, Coronado

94800

Local Institution - 0051, Villejuif

100000

Local Institution - 0175, Beijing

100142

Local Institution - 0152, Beijing

110004

Local Institution - 0123, Shenyang

110117

Local Institution - 0132, Shenyang

115478

Local Institution - 0007, Moscow

116023

Local Institution - 0131, Dalian

130021

Local Institution - 0162, Changchun

130102

Local Institution - 0166, Changchun

150081

Local Institution - 0135, Harbin

163045

Local Institution - 0029, Arkhangelsk

168583

Local Institution - 0048, Singapore

197758

Local Institution - 0075, Saint Petersburg

198255

Local Institution - 0091, Saint Petersburg

200032

Local Institution - 0134, Shanghai

200385

Local Institution, Craiova

200542

Local Institution - 0103, Craiova

210002

Local Institution - 0130, Nanjing

230022

Local Institution - 0120, Hefei

230601

Local Institution - 0146, Hefei

258499

Local Institution - 0017, Singapore

266000

Local Institution - 0153, Qingdao

300166

Local Institution - 0163, Timișoara

308442

Local Institution - 0174, Singapore

310000

Local Institution - 0108, Hangzhou

310022

Local Institution - 0107, Hangzhou

330006

Local Institution - 0145, Nanchang

330019

Local Institution - 0149, Nanchang

350002

Local Institution - 0151, Fuzhou

350014

Local Institution - 0121, Fuzhou

354057

Local Institution - 0073, Sochi

357502

Local Institution - 0072, Pyatigorsk

400015

Local Institution - 0165, Cluj-Napoca

400030

Local Institution - 0179, Chongqing

410006

Local Institution - 0109, Changsha

410011

Local Institution - 0059, Changsha

454087

Local Institution - 0074, Chelyabinsk

510000

Local Institution - 0125, Guangzhou

510515

Local Institution - 0150, Guangzhou

656045

Local Institution - 0066, Barnaul

710038

Local Institution - 0133, Xi'an

710061

Local Institution - 0147, Xi'an

710100

Local Institution - 0307, Xi'an

999077

Local Institution - 0036, Hong Kong

1720430

Local Institution - 0094, La Serena

2320024

Local Institution - 0200, Yokohama

2520598

Local Institution - 0012, Viña del Mar

2540402

Local Institution - 0216, Viña del Mar

2778577

Local Institution - 0193, Kashiwa-shi

3500495

Local Institution - 0258, Iruma-gun

4780000

Local Institution - 0296, Temuco

5458586

Local Institution - 0263, Abeno-ku

5898511

Local Institution - 0127, Sayama

7348551

Local Institution - 0177, Hiroshima

7630372

Local Institution - 0283, Santiago

7710007

Local Institution - 0024, Santiago

8380456

Local Institution - 0156, Santiago

8408571

Local Institution - 0281, Saga

41253190

Local Institution, Salvador

72115700

Local Institution - 0008, Federal District

91010-3012

Local Institution - 0157, Duarte

07103

Local Institution - 0295, Newark

C1090AAS

Local Institution - 0037, Caba

B1629ODT

Local Institution - 0194, Pilar

C1426ANZ

Local Institution - 0136, Buenos Aires

29055-450

Local Institution - 0278, Vitória

41950-640

Local Institution - 0061, Salvador

70200-730

Local Institution - 0181, Brasília

98700-000

Local Institution - 0279, Ijuí

96020-360

Local Institution - 0060, Pelotas

17210-120

Local Institution - 0054, Jaú

15090-000

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

81520-060

Local Institution - 0016, Paranã

22793-080

Local Institution - 0015, Rio de Janeiro

01246-000

Local Institution - 0023, São Paulo

01323-900

Local Institution - 0022, São Paulo

04038-034

Local Institution - 0050, São Paulo

T6G 1Z2

Local Institution - 0192, Edmonton

04103

Local Institution - 0118, Leipzig

Unknown

Local Institution - 0032, Hong Kong

00128

Local Institution - 0112, Roma

00168

Local Institution - 0079, Rome

790-0024

Local Institution - 0203, Matsuyama

920-8641

Local Institution - 0176, Kanazawa

241-8515

Local Institution - 0262, Yokohama

602-8566

Local Institution - 0189, Kyoto

634-8522

Local Institution - 0261, Kashihara

410-2295

Local Institution - 0259, Izunokuni-shi

105-8470

Local Institution - 0128, Minato

Local Institution - 0122, Minato-ku

181-8611

Local Institution - 0201, Mitaka

180-8610

Local Institution - 0199, Musashino-shi

260-8677

Local Institution - 0204, Chiba

830-0011

Local Institution - 0178, Fukuoka

0600033

Local Institution - 0155, Sapporo

05-400

Local Institution - 0049, Otwock

02-034

Local Institution - 0092, Warsaw

00935

Local Institution - 0289, Rio Piedras

00927-4308

Local Institution - 0035, San Juan

022328

Local Institution - 0164, Bucharest

03080

Local Institution - 0062, Jongno-gu

010408

Local Institution - 0097, Gyeonggi-do

050612

Local Institution - 0098, Gyeongsangnam-do

03722

Local Institution - 0141, Seoul

05505

Local Institution - 0140, Seoul

06351

Local Institution - 0139, Seoul

08035

Local Institution - 0297, Barcelona

08036

Local Institution - 0055, Barcelona

08908

Local Institution - 0089, Barcelona

W12 OHS

Local Institution - 0171, London

GU2 7XX

Local Institution - 0154, Guildford

EH4 2XU

Local Institution - 0160, Edinburgh

SE5 9RS

Local Institution - 0129, London

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY

NCT04039607 - A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma | Biotech Hunter | Biotech Hunter