Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

October 1, 2019

Primary Completion Date

August 31, 2027

Study Completion Date

August 31, 2027

Conditions
Metastatic Castrate Resistant Prostate CancerBARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2RAD51B, RAD51C, RAD51D, or RAD54L Mutations
Interventions
DRUG

Carboplatin

Chemotherapy FDA approved drug used to treat: ovarian, lung, head and neck cancers. It is sometimes used in combination with other medications or off-label use to treat other metastatic cancers.

DRUG

Olaparib

Olaparib is a targeted therapy drug that is used for mCRPC and is approved by the FDA for this use.

Trial Locations (18)

10010

RECRUITING

Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY, New York

19106

RECRUITING

Philadelphia MultiService Center, Philadelphia, PA, Philadelphia

30033

RECRUITING

Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur

32827

RECRUITING

Orlando VA Medical Center, Orlando, FL, Orlando

48105

RECRUITING

VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor

60612

TERMINATED

Jesse Brown VA Medical Center, Chicago, IL, Chicago

64128

RECRUITING

Kansas City VA Medical Center, Kansas City, MO, Kansas City

80045

RECRUITING

Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora

83702

RECRUITING

Boise VA Medical Center, Boise, ID, Boise

90073

RECRUITING

VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles

97239

RECRUITING

VA Portland Health Care System, Portland, OR, Portland

20422-0001

RECRUITING

Washington DC VA Medical Center, Washington, DC, Washington D.C.

33744-0000

TERMINATED

Bay Pines VA Healthcare System, Pay Pines, FL, Bay Pines

55417-2309

RECRUITING

Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis

10468-3904

TERMINATED

James J. Peters VA Medical Center, Bronx, NY, The Bronx

27705-3875

RECRUITING

Durham VA Medical Center, Durham, NC, Durham

98108-1532

RECRUITING

VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle

53705-2254

RECRUITING

William S. Middleton Memorial Veterans Hospital, Madison, WI, Madison

All Listed Sponsors
lead

VA Office of Research and Development

FED

NCT04038502 - Carboplatin or Olaparib for BRcA Deficient Prostate Cancer | Biotech Hunter | Biotech Hunter