Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

October 8, 2019

Primary Completion Date

July 1, 2024

Study Completion Date

September 26, 2025

Conditions
Prostate AdenocarcinomaStage IIC Prostate Cancer AJCC v8Stage III Prostate Cancer AJCC v8Stage IIIA Prostate Cancer AJCC v8Stage IIIB Prostate Cancer AJCC v8Stage IIIC Prostate Cancer AJCC v8Stage IVA Prostate Cancer AJCC v8
Interventions
BIOLOGICAL

Gonadotrophin Releasing Hormone

Receive standard of care GnRH agonist androgen suppression therapy

RADIATION

Intensity-Modulated Radiation Therapy

Undergo standard of care IMRT

DRUG

Niraparib

tablet

Trial Locations (95)

11355

The New York Hospital Medical Center of Queens, Flushing

11794

Stony Brook University Medical Center, Stony Brook

14263

Roswell Park Cancer Institute, Buffalo

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

UPMC-Shadyside Hospital, Pittsburgh

17044

Lewistown Hospital, Lewistown

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19124

Eastern Regional Medical Center, Philadelphia

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

20037

George Washington University Medical Center, Washington D.C.

21044

Central Maryland Radiation Oncology in Howard County, Columbia

21061

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

26506

West Virginia University Healthcare, Morgantown

29425

Medical University of South Carolina, Charleston

29605

Prisma Health Cancer Institute - Faris, Greenville

29607

Saint Francis Cancer Center, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29646

Self Regional Healthcare, Greenwood

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30265

CTCA at Southeastern Regional Medical Center, Newnan

30303

Grady Health System, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

39216

University of Mississippi Medical Center, Jackson

44106

Case Western Reserve University, Cleveland

44203

Summa Health System - Barberton Campus, Barberton

44256

Summa Health Medina Medical Center, Medina

44304

Summa Health System - Akron Campus, Akron

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48043

McLaren Cancer Institute-Macomb, Mount Clemens

48060

McLaren-Port Huron, Port Huron

48126

Henry Ford Medical Center-Fairlane, Dearborn

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48315

Henry Ford Macomb Health Center - Shelby Township, Shelby

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

Weisberg Cancer Treatment Center, Farmington Hills

48346

McLaren Cancer Institute-Clarkston, Clarkston

48377

Henry Ford Medical Center-Columbus, Novi

48446

McLaren Cancer Institute-Lapeer Region, Lapeer

48532

McLaren Cancer Institute-Flint, Flint

Singh and Arora Hematology Oncology PC, Flint

48706

McLaren Cancer Institute-Bay City, Bay City

48910

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing

48912

Mid-Michigan Physicians-Lansing, Lansing

49770

McLaren Cancer Institute-Northern Michigan, Petoskey

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53095

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53154

Drexel Town Square Health Center, Oak Creek

53188

UW Cancer Center at ProHealth Care, Waukesha

53226

Medical College of Wisconsin, Milwaukee

53295

Zablocki Veterans Administration Medical Center, Milwaukee

59405

Benefis Sletten Cancer Institute, Great Falls

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

61801

Carle Cancer Center, Urbana

62002

Alton Memorial Hospital, Alton

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64154

University of Kansas Cancer Center - North, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

73104

University of Oklahoma Health Sciences Center, Oklahoma City

85234

Banner MD Anderson Cancer Center, Gilbert

85704

University of Arizona Cancer Center-Orange Grove Campus, Tucson

85719

University of Arizona Cancer Center-North Campus, Tucson

90048

Cedars Sinai Medical Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

91786

City of Hope Upland, Upland

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95901

Fremont - Rideout Cancer Center, Marysville

02114

Massachusetts General Hospital Cancer Center, Boston

08210

AtlantiCare Health Park-Cape May Court House, Cape May Court House

08234

AtlantiCare Surgery Center, Egg Harbor

07101

Rutgers New Jersey Medical School, Newark

07666

Holy Name Hospital, Teaneck

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

T2N 5G2

Arthur J E Child Comprehensive Cancer Centre, Calgary

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER

NCT04037254 - Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring | Biotech Hunter | Biotech Hunter