Ketamine to Improve Recovery After Cesarean Delivery - Part 1

PHASE2CompletedINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

October 9, 2019

Primary Completion Date

August 1, 2021

Study Completion Date

August 1, 2021

Conditions
Obstetric PainPostpartum DepressionBreastfeedingPain, AcutePain, ChronicObstetric Anesthesia ProblemsDrug EffectOpioid Use
Interventions
DRUG

Ketamine

Subjects in the intervention arm will receive infusion dosing as noted in arm/group descriptions at the time of cord clamping. Duration of infusion will be 12 hours. Concentrations of ketamine and ketamine metabolites (nor-ketamine, NKET; and dehydro-nor-ketamine, DHNK) are measured in maternal plasma and urine as well as breastmilk. Maternal side effects, adverse events, and efficacy endpoints will be measured over the 12 hour infusion and over 15 hours after infusion discontinuation.

Trial Locations (2)

15213

UPMC Montefiore Hospital CTRC, Pittsburgh

15232

Minhnoi C Wroble Biglan, Pittsburgh

All Listed Sponsors
collaborator

University of Pittsburgh

OTHER

lead

Grace Lim, MD, MS

OTHER

NCT04037085 - Ketamine to Improve Recovery After Cesarean Delivery - Part 1 | Biotech Hunter | Biotech Hunter