A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

587

Participants

Timeline

Start Date

July 2, 2019

Primary Completion Date

April 3, 2023

Study Completion Date

December 22, 2026

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Osimertinib

"Drug: Osimertinib (Oral)~Other Names:~AZD9291"

DRUG

Pemetrexed/Carboplatin

Drug: Pemetrexed (500 mg/m2) plus carboplatin (AUC5) on Day 1 of 21day cycles (every 3 weeks) for 4 cycles, followed by Osimertinib daily with pemetrexed maintenance (500 mg/m2) every 3 weeks.

DRUG

Pemetrexed/Cisplatin

Drug: Pemetrexed (500 mg/m2) plus cisplatin (75 mg/m2) on Day 1 of 21day cycles (every 3 weeks) for 4 cycles, followed by Osimertinib daily with pemetrexed maintenance (500 mg/m2) every 3 weeks.

Trial Locations (153)

27

Research Site, San Isidro

500

Research Site, Changhua

1100

Research Site, Quezon City

1112

Research Site, Quezon City

1280

Research Site, Ciudad de Buenos Aires

1740

Research Site, Las Piñas

2000

Research Site, Santa Fe

2050

Research Site, Camperdown

2196

Research Site, Johannesburg

2217

Research Site, Kogarah

3000

Research Site, Melbourne

3084

Research Site, Heidelberg

4032

Research Site, Chermside

4500

Research Site, Legaspi

5000

Research Site, Iloilo City

5001

Research Site, Córdoba

5112

Research Site, Elizabeth Vale

6000

Research Site, Cebu City

6045

Research Site, Port Elizabeth

7700

Research Site, Rondebosch

8000

Research Site, Davao City

10002

Research Site, Taipei

10210

Research Site, Bangkok

10330

Research Site, Bangkok

10400

Research Site, Bangkok

10408

Research Site, Goyang-si

12208

Research Site, Albany

15036

Research Site, Lima

15212

Research Site, Pittsburgh

15232

Research Site, Pittsburgh

19104

Research Site, Philadelphia

22031

Research Site, Fairfax

23561

Research Site, Taipei

24060

Research Site, Blacksburg

28644

Research Site, Cheongju-si

32804

Research Site, Orlando

33075

Research Site, Bordeaux

33612

Research Site, Tampa

34298

Research Site, Montpellier

40002

Research Site, Khon Kaen

40202

Research Site, Louisville

40447

Research Site, Taichung

40705

Research Site, Taichung

44710

Research Site, Canton

50200

Research Site, Muang

66160

Research Site, Kansas City

69373

Research Site, Lyon

70000

Research Site, Ho Chi Minh City

77090

Research Site, Houston

78240

Research Site, San Antonio

82606

Research Site, Bratislava

89074

Research Site, Henderson

90048

Research Site, West Hollywood

90110

Research Site, Hat Yai

90404

Research Site, Santa Monica

90602

Research Site, Whittier

90706

Research Site, Bellflower

92093

Research Site, La Jolla

92835

Research Site, Fullerton

94805

Research Site, Villejuif

95403

Research Site, Santa Rosa

97002

Research Site, Hualien City

98684

Research Site, Vancouver

100000

Research Site, Hanoi

100142

Research Site, Beijing

100191

Research Site, Beijing

100853

Research Site, Beijing

110001

Research Site, Shenyang

115478

Research Site, Moscow

122001

Research Site, Gūrgaon

130000

Research Site, Changchun

143423

Research Site, Moscow

150081

Research Site, Harbin

167904

Research Site, Syktyvkar

183047

Research Site, Murmansk

194356

Research Site, Saint Petersburg

197758

Research Site, Saint Petersburg

198255

Research Site, Saint Petersburg

200030

Research Site, Shanghai

200032

Research Site, Shanghai

210009

Research Site, Nanjing

230001

Research Site, Hefei

250001

Research Site, Jinan

310003

Research Site, Hangzhou

310022

Research Site, Hangzhou

400030

Research Site, Chongqing

410013

Research Site, Changsha

411004

Research Site, Pune

430030

Research Site, Wuhan

450008

Research Site, Zhengzhou

510515

Research Site, Guangzhou

560027

Research Site, Bengaluru

570312

Research Site, Haikou

590010

Research Site, Belagavi

610041

Research Site, Chengdu

700160

Research Site, Kolkata

710061

Research Site, Xi'an

830000

Research Site, Ürümqi

2540488

Research Site, Viña del Mar

4810469

Research Site, Temuco

7500713

Research Site, Santiago

8420383

Research Site, Santiago

02215

Research Site, Boston

C1056ABJ

Research Site, Buenos Aires

C1125ABD

Research Site, Buenos Aires

C1012AAR

Research Site, CABA

C1019ABS

Research Site, CABA

14784-400

Research Site, Barretos

88034-000

Research Site, Florianópolis

86015-520

Research Site, Londrina

91350-200

Research Site, Porto Alegre

14021-636

Research Site, Ribeirão Preto

15090-000

Research Site, São José do Rio Preto

01246-000

Research Site, São Paulo

04029-000

Research Site, São Paulo

29043-260

Research Site, Vitória

T2N 5G2

Research Site, Calgary

T6G 1Z2

Research Site, Edmonton

M5G 2M9

Research Site, Toronto

775 21

Research Site, Olomouc

703 84

Research Site, Ostrava - Vitkovice

140 59

Research Site, Prague

150 06

Research Site, Prague

110 085

Research Site, New Delhi

113-8431

Research Site, Bunkyō City

113-8603

Research Site, Bunkyō City

812-8582

Research Site, Fukuoka

350-1298

Research Site, Hidaka-shi

670-8520

Research Site, Himeji-shi

740-8510

Research Site, Iwakuni-shi

920-8641

Research Site, Kanazawa

227-8577

Research Site, Kashiwa

135-8550

Research Site, Kōtoku

541-8567

Research Site, Osaka

591-8555

Research Site, Sakaishi

003-0804

Research Site, Sapporo

981-0914

Research Site, Sendai

411-8777

Research Site, Sunto-gun

241-8515

Research Site, Yokohama

AREQUIPA01

Research Site, Arequipa

Lima 32

Research Site, Lima

LIMA 34

Research Site, Lima

041 91

Research Site, Košice

05801

Research Site, Poprad

03080

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

00807

Research Site, Kaohsiung City

CB2 0QQ

Research Site, Cambridge

LE1 5WW

Research Site, Leicester

L7 8YA

Research Site, Liverpool

ME16 9QQ

Research Site, Maidstone

M20 4BX

Research Site, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY