1,013
Participants
Start Date
August 12, 2019
Primary Completion Date
January 15, 2025
Study Completion Date
January 19, 2028
Ocrelizumab
The first dose of ocrelizumab will be administered as two 300 milligrams (mg), IV infusions given 14 days apart. For the subsequent doses, ocrelizumab will be administered as a single 600 mg infusion every 24 weeks. A minimum interval of 20 or 22 weeks, depending on if the previous dose was administered in one or two infusion, should be maintained between each infusion.
Placebo
The first dose of placebo will be administered as two IV infusions given 14 days apart. For the subsequent doses, placebo will be administered as a single infusion every 24 weeks, with a minimum interval of 20 or 22 weeks, depending on if the previous dose was administered in one or two infusions, maintained between each infusion.
Khechinashvili University Hospital, Tbilisi
Military Hospital of Tunis, Tunis
Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv. Naum EAD, Sofia
Cliniques Universitaires St-Luc, Brussels
Hopital Razi, LA Mannouba
Brain and Mind Research Institute, Camperdown
UZ Antwerpen, Edegem
Hospital Habib Bourguiba, Sfax
Royal Melbourne Hospital, Parkville
Austin Hospital, Heidelberg
MS & Neurologisch Revalidatie Centrum, Overpelt
Fattouma Bourguiba University Hospital, Monastir
Military Medical Academy HBAT, Pleven
Multiprofile Hospital For Active Treatment Avis Medica, Pleven
New Zealand Clinical Research - Christchurch, Christchurch
Clinical Hospital Sestre Milosrdnice, Zagreb
University Hospital Center Zagreb, Zagreb
Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano
Centre Hospitalier Ibn Sina CHIS - Hopital des Specialites, Rabat
Military Medical Academy, Belgrade
University Clinical Center of Serbia -PPDS, Belgrade
Clinical Hospital Centre Zemun, Belgrade
Unidad de Investigacion en Salud de Chihuahua, Mexico City
IRCCS Ospedale Policlinico San Martino, Genoa
Clinical Center Nis, Niš
Albert Einstein Medical Center, Philadelphia
Georgetown University Medical Center, Washington D.C.
Ospedale San Raffaele S.r.l. - PPDS, Milan
Clinical Centre of Vojvodina, Nova Sad
Medical Center Salutem, Vinnytsia
LLC Medical Center Health Clinic, Vinnytsia
Treatment and Diagnostic Center of LLC MRT Elit, Kropyvnytskyi
Fondazione Istituto Neurologico Mondino IRCCS, Pavia
Hospital Universitario Ramon y Cajal, Madrid
Hospital Universitario Puerta de Hierro - Majadahonda, Madrid
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón
Hospital Universitario Virgen de La Arrixaca, El Palmar
CHU de Nimes - Hopital Universitaire Caremeau, Nîmes
Clinical Hospital Centre Osijek, Osijek
General Hospital Uzice, Užice
Hospital Angeles Chihuahua, Chihuahua City
Neurological Services of Orlando, Orlando
Vero Neurology, Vero Beach
CHU de Bordeaux - Hôpital Pellegrin, Bordeaux
MS and Neuromuscular Center of Excellence, Clearwater
University Clinical Center Kragujevac, Kragujevac
Complejo Hospitalario Universitario de Vigo, Vigo
Complejo Asistencial Universitario de Salamanca ? H. Clinico, Salamanca
CHU Mohammed VI, Marrakesh
Hospital Universitario Virgen Macarena, Seville
General Hospital Varazdin, Varaždin
Volyn Regional Clinical Hospital, Lutsk
Hopital Guillaume Et Rene Laennec, Nantes
Hospital Universitari i Politecnic La Fe de Valencia, Valencia
Michigan Neurology Associates P.C., Clinton Township
University hospital of Dnipro State Medical University, Dnipro
LLC Medical Center Family Medicine Clinic, Dnipro
Instituto Neurologico de Colombia INDEC, Medellín
CHRU Nancy, Nancy
Clinical Research Institute, Tlalnepantla
Communal Non-commercial Enterprise of Kharkiv Regional Council Regional Clinical Hospital, Kharkiv
Centre Hospitalier Universitaire de Clermont Ferrand, Clermont-Ferrand
University of Kansas Medical Center, Kansas City
Hopital Civil, Strasbourg
LLC Medical Center Unimed, Zaporizhzhia
LLC Medical Center INET 09, Zaporizhzhia
Municipal Non-profit Enterprise Zaporizhzhya Regional Hospital Zaporizhzhya Regional Council, Zaporizhzhia
Municipal Non-profit Enterprise Kherson City Clinical Hospital named after Ye.Ye. Karabelesh, Kherson
Treatment and diagnostic Center Neuro Global of LLC Neuro Global, Krykhivtsi
Maxine Mesinger MS Clinic/Baylor College of Medicine, Houston
Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital, Lviv
Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital, Lviv
Neurociencias Estudios Clinicos S.C., Culiacán
AOU dell Universita degli Studi della Campania Luigi Vanvitelli Piazza Luigi Miraglia 2, Napoli
Municipal NPE Regional Clinical Center of Neurosurgery and Neurology of Transcarpathian RC, Uzhhorod
Fondazione Istituto G. Giglio di Cefalu, Cefalù
Multiple Sclerosis Center of California, Laguna Hills
Clinica Colsanitas S.A. sede Clinica Universitaria Colombia, Bogotá
SC Clubul Sanatatii SRL, Campulung Muscel
City Clinical Hospital a n Buyanov V M, Moscow
Research Center of Neurology of RAMS, Moskva
City Clinical Hospital #24, Moscow
Moscow Regional Research Clinical Institute Na Mfvladimirskiy, Moscow
National Center of Socially Significant Diseases, Saint Petersburg
City Hospital #40 of Kurortniy Administrative District, Saint Petersburg
Spitalul Judetean de Urgenta Deva, Deva
Vertebronevrologiya LLC, Kazan'
City Clinical Hospital #4, Saransk
Ulyanovsk Regional Clinical Hospital, Ulyanovsk
Targu Mures Clinical Emergency County Hospital, Târgu Mure?
Nizhegorodskaya Regional Clinical Hospital n.a. Semashko, Nizhny Novgorod
MEDIS Limited Liability Company, Nizhny Novgorod
SBHI of Nizhny Novgorod region City Clinical Hospital #3, Nizhny Novgorod
Kirov State Medical Academy, Kirov
Perm Regional Clinical Hospital of Znak Pocheta Medal, Perm
Sverdlovsk Regional Clinical Hospital 1, Yekaterinburg
Neftyanik Medical and Sanitary Unit, Tumen
FSBIH Siberian Regional Medical Centre of FMBA of Russia, Novosibirsk
Siberian State Medical University of Roszdrav, Tomsk
Belyayev Clinical Hospital of the Kuzbass, Kemerovo
Krasnoyarsk State Medical Academy, Krasnoyarsk
Cai Ferate Clinical Hospital, Constanța
The Boster Center for MS, Columbus
Columbus Neuroscience, Westerville
University of Alberta, Edmonton
Dalhousie Multiple Sclerosis Research Unit, Halifax
St. Michael's Hospital, Toronto
Recherche Sepmus Inc., Greenfield Park
Pineo Medical Ecosystem LTD, Tbilisi
The First University Clinic of Tbilisi State Medical University, Tbilisi
Fondazione PTV Policlinico Tor Vergata, Rome
Azienda Ospedaliera Sant'andrea, Rome
Hotel Dieu de France, Achrafieh Beirut
Saint George University Medical Hospital, El Achrafiyé
Grupo Medico Camino, Mexico City
Dunedin Hospital, Dunedin
Neurocentrum Bydgoszcz sp z o.o, Bydgoszcz
Przychodnia EuroMediCare, Wroclaw
Rejdak Konrad Indywidualna Praktyka Lekarska dr hab. Konrad Rejdak, Lublin
Centrum Medyczne Medyk, Rzeszów
SPZOZ Wojewodzki Szpital Specjalistyczny nr 3, Rybnik
Uniwersytecki Szpital Kliniczny w Bialymstoku Marii Sklodowskiej Curie 24a, Bia?ystok
Copernicus Podmiot Leczniczy Sp z o o, Gda?sk
Mazowieckie Centrum Badan Klinicznych, Grodzisk Mazowiecki
MA-LEK Clinical Sp. Z o.o., Katowice
Novo-Med Zielinski i wsp SpJ, Katowice
NEURO-MEDIC Sp. z o. o., Katowice
Specjalistyczna Praktyka Lekarska Dr n.med. Stanislaw Ochudlo, Katowice
Szpital Uniwersytecki w Krakowie, Krakow
Centrum Neurologii Krzysztof Selmaj, Lodz
Galen Clinic, Lublin
Wojewodzki Szpital Specjalistyczny, Olsztyn
Med-Polonia Sp. z o.o., Poznan
EUROMEDIS Sp z o o, Szczecin
Centrum Medyczne NeuroProtect Zablocinska 10, Warsaw
RESMEDICA Spolka z o.o., Kielce
ULS de Loures-Odivelas, EPE - Hospital de Loures, Loures
Hospital Garcia de Orta, Almada
Hospital de Braga, Braga
Hospital de Santo Antonio, Porto
Campus Neurologico Senior, Torres Vedras
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
Medical Centre of PE First Private Clinic, Kyiv
Kyiv City Clinical Hospital #4, Kyiv
Communal Non-Commercial Enterprise Clinical Hospital #15 of the Podilskyi District ofthe Kyiv City, Kyiv
Medical Center Artes Medicum LLC, Kyiv
Medical Center of LLC Medical Center Dopomoga Plus, Kyiv
Private Enterprise Clinic Medicom, Kyiv
University Hospital of Wales, Cardiff
Queen Elizabeth University Hospital - PPDS, Glasgow
Raigmore Hospital - PPDS, Inverness
The Royal London Hospital, London
The National Hospital for Neurology & Neurosurgery, London, GT LON
University of Nottingham, Nottingham
Peninsula College of Medicine and Dentistry, Plymouth
Salford Royal Hospital, Salford
Royal Hallamshire Hospital, Sheffield
Morriston Hospital, Swansea
Hoffmann-La Roche
INDUSTRY