250
Participants
Start Date
January 20, 2021
Primary Completion Date
April 21, 2027
Study Completion Date
April 21, 2028
Surgery
Large en-bloc curative-intent surgery
Preoperative chemotherapy
"* High grade LPS: ADM 75 mg/m2 (or the equivalent EpiADM 120 mg/m2) + ifosfamide 9 g/m2 Q3 weeks~* LMS: ADM 75 mg/m2 + DTIC 1g/m2 Q3 weeks~Note: the recommended dose of Doxorubicin (or Epirubicin) can be modified according to national/institutional guidelines, given that the minimal threshold must be Doxorubicin 60 mg/m2 per cycle (or the equivalent Epirubicin 95 mg/m2 per cycle); the recommended dose of Ifosfamide can be modified according to national/institutional guidelines, given that the minimal threshold must be 7.5 g/m2 per cycle; the recommended dose of Dacarbazine can be modified according to national/institutional guidelines, given that the minimal threshold must be 900 mg/m2 per cycle. The schedule of administration of above chemotherapies can be modified according to national/institutional guidelines provided that the minimal threshold of doses, and the treatment periods with chemotherapies remain the same."
RECRUITING
The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis, Amsterdam
RECRUITING
Bank Of Cyprus Oncology Centre, Stróvolos
RECRUITING
Chris O'Brian Life House - Chris O'Brien Lifehouse, Camperdown
RECRUITING
Herlev Hospital - University Copenhagen, Herlev
RECRUITING
Peter Maccallum Cancer Institute, Melbourne
RECRUITING
Radboudumc - Radboud University Medical Center Nijmegen, Nijmegen
RECRUITING
Aarhus University Hospitals - Aarhus University Hospital-Skejby, Aarhus
RECRUITING
Laura and Issac Perlmutter Ca Ctr at NYU Langone, New York
RECRUITING
NYU Langone Hospital - Long Island, Mineola
RECRUITING
Stony Brook University Medical Center, Stony Brook
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
University of Rochester, Rochester
RECRUITING
Jefferson Hospital, Jefferson Hills
RECRUITING
Allegheny Valley Hospital, Natrona Heights
RECRUITING
Wexford Health and Wellness Pavilion, Wexford
RECRUITING
Forbes Hospital, Monroeville
RECRUITING
Allegheny General Hospital, Pittsburgh
RECRUITING
West Penn Hospital, Pittsburgh
RECRUITING
UPMC Hillman Cancer Center, Pittsburgh
RECRUITING
Saint Vincent Hospital, Erie
RECRUITING
University of Pennsylvania/Abramson Cancer Center, Philadelphia
RECRUITING
Pennsylvania Hospital, Philadelphia
RECRUITING
Thomas Jefferson University Hospital, Philadelphia
RECRUITING
Fox Chase Cancer Center, Philadelphia
RECRUITING
IRCCS - Istituto Nazionale dei Tumori, Milan
RECRUITING
Johns Hopkins Univ/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
VCU Massey Cancer Center at Hanover Medical Park, Mechanicsville
RECRUITING
VCU Massey Cancer Center at Stony Point, Richmond
RECRUITING
Virginia Commonwealth Univ/Massey Cancer Center, Richmond
RECRUITING
VCU Community Memorial Health Center, South Hill
RECRUITING
Carilion Roanoke Memorial Hospital, Roanoke
RECRUITING
Duke University Medical Center, Durham
RECRUITING
Hospital General Universitario Gregorio Maranon, Madrid
RECRUITING
Hospital Universitario San Carlos, Madrid
RECRUITING
Emory University Hospital Midtown, Atlanta
RECRUITING
Mayo Clinic in Florida, Jacksonville
RECRUITING
Centro Di Riferimento Oncologico, Aviano
RECRUITING
Moffitt Cancer Center-International Plaza, Tampa
RECRUITING
Moffitt Cancer Center - McKinley Campus, Tampa
RECRUITING
Moffitt Cancer Center, Tampa
RECRUITING
Institut du Cancer de Montpellier, Montpellier
RECRUITING
Universitaetsmedizin Goettingen - Georg-August Universitaet, Goettigen
RECRUITING
Vanderbilt University/Ingram Cancer Center, Nashville
RECRUITING
James Graham Brown Ca Ctr at Univ of Louisville, Louisville
RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
Indiana Univ/Melvin and Bren Simon Cancer Center, Indianapolis
RECRUITING
University of Michigan Comprehensive Cancer Center, Ann Arbor
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
Marshfield Medical Center, Marshfield
RECRUITING
Marshfield Medical Center, Weston
RECRUITING
Marshfield Med Ctr-River Region at Stevens Point, Stevens Point
RECRUITING
Marshfield Medical Center, Minocqua
RECRUITING
Marshfield Medical Center-EC Cancer Center, Eau Claire
RECRUITING
Marshfield Medical Center, Rice Lake
RECRUITING
Mayo Clinic, Rochester
RECRUITING
Sanford Joe Lueken Cancer Center, Bemidji
RECRUITING
Sanford Cancer Center Oncology Clinic, Sioux Falls
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
Sanford Roger Maris Cancer Center, Fargo
RECRUITING
Sanford Bismarck Medical Center, Bismarck
RECRUITING
Northwestern University, Chicago
RECRUITING
University of Illinois at Chicago MBCCOP, Chicago
RECRUITING
Washington University School of Medicine - Siteman Cancer Center, St Louis
RECRUITING
Siteman Cancer Center-South Country, St Louis
RECRUITING
Siteman Cancer Center-West County, Creve Coeur
RECRUITING
University of Kansas Cancer Center, Kansas City
RECRUITING
University of Kansas Hospital-Westwood Cancer Ctr, Westwood
RECRUITING
University of Kansas Cancer Center-Overland Park, Overland Park
RECRUITING
Hopitaux Universitaires de Strasbourg - Hautepierre, Strasbourg
RECRUITING
Nebraska Medicine-Bellevue, Omaha
RECRUITING
Nebraska Medicine-Bellevue, Bellevue
RECRUITING
UniversitaetsMedizin Mannheim, Mannheim
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Centre Leon Berard, Lyon
RECRUITING
LSU Health Baton Rouge-North Clinic, Baton Rouge
RECRUITING
Our Lady of The Lake Hospital, Baton Rouge
RECRUITING
Our Lady of the Lake Physician Group, Baton Rouge
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Institut Curie- Hopital de Paris, Paris
RECRUITING
M D Anderson Cancer Center, Houston
RECRUITING
UCHealth University of Colorado Hospital, Aurora
RECRUITING
Huntsman Cancer Institute/University of Utah, Salt Lake City
RECRUITING
Mayo Clinic Hospital in Arizona, Phoenix
RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
UC Irvine Health/Chao Family Comprehensive Ca Ctr, Orange
RECRUITING
Institut Gustave Roussy, Villejuif
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
FHCC South Lake Union, Seattle
RECRUITING
Fred Hutchinson Cancer Center, Seattle
RECRUITING
University of Washington Medical Center - Montlake, Seattle
RECRUITING
Smilow Cancer Hospital-Derby Care Center, Derby
RECRUITING
Smilow Cancer Hospital Care Center-Fairfield, Fairfield
RECRUITING
Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury
RECRUITING
Smilow Cancer Hospital Care Center at Greenwich, Greenwich
RECRUITING
Smilow Cancer Hospital Care Center - Guiford, Guilford
RECRUITING
Smilow Cancer Hospital Care Ctr at Saint Francis, Hartford
RECRUITING
Yale University, New Haven
RECRUITING
Yale-New Haven Hospital North Haven Medical Center, North Haven
RECRUITING
Smilow Cancer Hospital Care Center - Waterford, Waterford
RECRUITING
Smilow Cancer Hospital Care Center at Long Ridge, Stamford
RECRUITING
Smilow Cancer Hospital Care Center-Trumbull, Trumbull
RECRUITING
Smilow Cancer Hospital-Waterbury Care Center, Waterbury
RECRUITING
Dana-Farber/Harvard Cancer Center, Boston
RECRUITING
Dartmouth Hitchcock Med Ctr/Dartmouth Cancer Ctr, Lebanon
RECRUITING
HMH-Hackensack University Medical Center, Hackensack
RECRUITING
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
Rhode Island Hospital, Providence
RECRUITING
Smilow Cancer Hospital Care Center - Westerly, Westerly
RECRUITING
Princess Alexandra Hospital - University Of Queensland, Woolloongabba
RECRUITING
BCCA - Vancouver Cancer Centre, Vancouver
RECRUITING
London Regional Cancer Center, London
RECRUITING
The Ottawa Hospital - General Campus, Ottawa
RECRUITING
Mount Sinai Hospital, Toronto
RECRUITING
IRCCS - Fondazione Piemonte Inst di Candiolo, Candiolo
RECRUITING
"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori", Meldola
RECRUITING
Istituto Clinico Humanitas, Milan
RECRUITING
Istituto Europeo di Oncologia, Milan
RECRUITING
IRCCS - Istituto Oncologico Veneto, Padua
RECRUITING
Policlinico Universitario Campus Bio-Medico- Oncology Center, Roma
RECRUITING
Maria Sklodowska-Curie Memorial Cancer Centre - Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw
RECRUITING
Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol, Barcelona
RECRUITING
NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital, Glasgow
RECRUITING
the Royal Marsden Hospital, London
RECRUITING
Hopital Maisonneuve Rosemont, Montreal
RECRUITING
The Research Institute of the McGill University Health Centre, Montreal
RECRUITING
Masaryk Memorial Cancer Institute, Brno
RECRUITING
Universitaetsklinikum Carl Gustav Carus, Dresden
RECRUITING
Kyushu University Hospital, Higashiku
RECRUITING
Yokohama City University Hospital, Yokohama
RECRUITING
Kanagawa Cancer Center, Yokohama
RECRUITING
Tohoku University Hospital, Sendai
RECRUITING
Aichi Cancer Center, Chikusa-ku
RECRUITING
Nagoya University Hospital, Shōwaku
RECRUITING
Niigata University Medical and Dental Hospital, Niigata
RECRUITING
Okayama University Hospital, Kita-ku
RECRUITING
Osaka International Cancer Institute, Chuo-ku
RECRUITING
National Cancer Center Hospital, Chuo-ku
RECRUITING
Cancer Institute Hospital of JFCR, Koto-ku
RECRUITING
Saitama Medical Center, Jichi Medical University, Saitama
RECRUITING
Leiden University Medical Centre, Leiden
RECRUITING
National Cancer Institute, Bratislava
RECRUITING
Hospital De La Santa Creu I Sant Pau, Barcelona
RECRUITING
University Hospitals Birmingham - Queen Elisabeth Medical Centre, Birmingham
RECRUITING
Leeds Teaching Hospitals NHS Trust - St. James's University Hospital, Leeds
RECRUITING
Clatterbridge cancer center, Metropolitan Borough of Wirral
NOT_YET_RECRUITING
Newcastle Hospitals - Freeman Hospital, Northern Centre For Cancer Care, Newcastle
RECRUITING
Nottingham University Hospitals NHS Trust - City Hospital, Nottingham
RECRUITING
Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford
Canadian Cancer Trials Group
NETWORK
ECOG-ACRIN Cancer Research Group
NETWORK
Anticancer Fund, Belgium
OTHER
Australia and New Zealand Sarcoma Association
UNKNOWN
Japan Clinical Oncology Group
OTHER
European Organisation for Research and Treatment of Cancer - EORTC
NETWORK