Prostate-Specific Membrane Antigen (PSMA) PET Scans in People Prostate Cancer

Participants will be injected intravenously with a bolus of 7-10 mCi of 18F-DCFPyL.

Participants will be injected intravenously with a bolus of 3-8 mCi of 68Ga-HBED-iPSMA

The baseline PSMA PET scan may be performed externally or at MSKCC, but all follow-up imaging must be performed at MSKCC. Approximately 60-90 minutes after intravenous injection of radiotracer, patients will be scanned from the mid-skull to the mid-thigh. Imaging will start with a low-dose CT for attenuation correction, followed by a PET scan. Upon completion of imaging and at the discretion of the investigator, the patient may be asked to void and get back in the scanner for 1 additional image of the pelvis.This additional image allows investigator's to see an unobstructed view of the prostate/prostate bed