Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)

PHASE3CompletedINTERVENTIONAL
Enrollment

165

Participants

Timeline

Start Date

October 8, 2019

Primary Completion Date

April 11, 2025

Study Completion Date

April 11, 2025

Conditions
Type 2 Diabetes Mellitus
Interventions
DRUG

Ertugliflozin 5 mg

Ertugliflozin 5 mg, oral, 1 tablet QD

DRUG

Ertugliflozin 15 mg

Ertugliflozin 15 mg, oral, 1 tablet QD

DRUG

Placebo to ertugliflozin 15 mg

Placebo to ertugliflozin 15 mg, oral, 1 tablet QD

DRUG

Placebo to ertugliflozin 5 mg

Placebo to ertugliflozin 5 mg, oral, 1 tablet QD

BIOLOGICAL

Insulin

The initiation and titration of insulin will be at the discretion of the investigator, based on local/regional/country guidelines.

DRUG

Metformin

Participants will receive stable dose of background metformin.

Trial Locations (104)

1089

Heim Pal Orszagos Gyermekgyogyaszati Intezet ( Site 0702), Budapest

1094

Semmelweis Egyetem II. sz. Gyermekgyogyaszati Klinika ( Site 0703), Budapest

1200

Cliniques Universitaires Saint-Luc ( Site 2300), Brussels

1810

Institute for Studies on Diabetes Foundation Inc. ( Site 1402), Marikina City

3526

Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi OktatoKorhaz ( Site 0701), Miskolc

4184

Thumbay University Hospital ( Site 2001), Ajman

4400

Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 0704), Nyíregyháza

5000

West Visayas State University Medical Center ( Site 1401), Iloilo City

5166

Rashid Center For Diabetes and Research ( Site 2006), Ajman

5600

Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház-Gyermekosztály ( Site 0705), Békéscsaba

7623

Pecsi Tudomanyegyetem Klinikai Kozpont Gyermekgyogyaszati Klinika ( Site 0708), Pécs

7662

Al Jalila Children s Specialty Hospital ( Site 2004), Dubai

8000

Vita Verum Medical Egeszsegugyi Szolgaltato Bt ( Site 0706), Székesfehérvár

Davao Doctors Hospital ( Site 1400), Davao City

9023

Petz Aladar Megyei Oktato Korhaz ( Site 0709), Győr

10101

Hospital Infantil Dr. Robert Reid Cabral ( Site 0300), Santo Domingo

10126

Ospedale Regina Margherita ( Site 0905), Torino

10455

CHEAR Center LLC ( Site 2200), The Bronx

10990

Hospital Pulau Pinang. ( Site 1101), George Town

11410

Bio Investigación AMARC, S.C. ( Site 1006), Mexico City

11426

King Abdul Aziz Medical City - AlRiyadh ( Site 1700), Riyadh

King Abdul Aziz Medical City - AlRiyadh ( Site 1705), Riyadh

11501

Clinica Los Yoses ( Site 0200), San José

11564

King Salman bin Abdulaziz hospital - Al Riyadh ( Site 1720), Riyadh

King Salman bin Abdulaziz hospital Al Riyadh ( Site 1710), Riyadh

16147

IRCCS G. Gaslini ( Site 0900), Genova

16150

Hospital Universiti Sains Malaysia ( Site 1102), Kubang Kerian

19104

The Children's Hospital of Philadelphia ( Site 2205), Philadelphia

20001

Consultorio Privado Dr. Geraldine Utrilla ( Site 0501), Chiquimula

20116

Centro de Investigacion Medica Aguascalientes ( Site 1000), Aguascalientes

20119

Centro de Atencion e Investigacion Clinica SC ( Site 1009), Aguascalientes

21010

Vinnitsa Regional Endocrinology Dispensary, VNMU n.a. M.I.Pyrogov ( Site 1901), Vinnytsia

21014

Life Nova+ ( Site 1203), Forbach

21079

CHU du BOCAGE ( Site 0407), Dijon

21229

Barry J. Reiner MD LLC ( Site 2204), Baltimore

21423

King Abdul Aziz Medical City. National Guard Health Affairs ( Site 1715), Jeddah

24211

Hera General Hospital ( Site 1725), Mecca

28403

Coastal Children''s Services ( Site 2202), Wilmington

31982

King Abdulaziz Medical City - Al Ahsa ( Site 1730), Al Ahsa

33021

Memorial Regional Hospital-Joe DiMaggio Children's Hospital Division of Pediatric Endocrinology ( Si, Hollywood

34000

Hospital Taiping ( Site 1104), Taiping

34098

I. U. Cerrahpasa Tip Fakultesi ( Site 2406), Istanbul

34854

Marmara Üniversitesi Prof. Dr. Asaf Ataseven Hospital ( Site 2400), Istanbul

44150

Unidad de Investigacion Clinica Cardiometabolica de Occidente ( Site 1007), Guadalajara

44260

Centro de Investigacion Medica de Occidente S.C. ( Site 1001), Guadalajara

48073

William Beaumont Hospital ( Site 2219), Royal Oak

49100

SI Dnipropetrovsk Regional Children Clinical Hospital DOR ( Site 1914), Dnipro

50139

A.O.Universitaria Meyer ( Site 0901), Florence

58002

Chernivtsi Regional Children Clinical Hospital No. 1-Department of Pediatrics and Medical Genetics (, Chernivtsi

59100

University Malaya Medical Centre ( Site 1100), Kuala Lumpur

60659

ICCT Research International, Inc. ( Site 2211), Chicago

61093

MHI Regional Childrens Clinical Hospital ( Site 1908), Kharkiv

61153

Institute of Children and Adolescents Health Care of the Academy of Medical Sciences ( Site 1915), Kharkiv

62000

Hospital Putrajaya ( Site 1103), Putrajaya

64460

Unidad Biomedica Avanzada Monterrey S. A. ( Site 1005), Monterrey

65031

Odessa Regional Children Clinical Hospital ( Site 1912), Odesa

75149

Southern Endocrinology and Associates PA ( Site 2218), Mesquite

76800

Unidad de Medicina Especializada SMA ( Site 1004), San Juan del Río

80000

Consultorio Medico de Endocrinologia Pediatrica ( Site 1002), Culiacán

80054

CHU Amiens Hopital Sud ( Site 0413), Amiens

80123

AOU Federico II di Napoli ( Site 0902), Napoli

80812

Wellkin Hospital ( Site 1200), Moka

89440

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 1003), Madero

90027

Children's Hospital - Los Angeles ( Site 2201), Los Angeles

93100

U.O. di Diabetologia dell'Eta Evolutiva - AUSL 2 ( Site 0904), Caltanissetta

95821

Center of Excellence in Diabetes and Endocrinology ( Site 2203), Sacramento

110221

MedPlus Medicina Prepagada S.A. ( Site 0102), Bogotá

117036

Federal State Budget Institution Endocrinological Research Center ( Site 1611), Moscow

194100

St.Petersburg State Pediatric Medical University ( Site 1600), Saint Petersburg

215252

Dubai Diabetes Center ( Site 2002), Dubai

344012

Rostov Scientific Research Institution of Obstetrics and Pediatry ( Site 1606), Rostov-on-Don

394024

Voronezh State Medical University named after N.N.Burdenko ( Site 1608), Voronezh

420029

Kazan State Medical University ( Site 1601), Kazan'

443079

Samara City Pediatric Clinical Hospital n.a. N.N. Ivanova ( Site 1610), Samara

445498

Mustafa Al Qaysi Medical Centre ( Site 2010), Dubai

450083

Bashkir State Medical University Hospital ( Site 1603), Ufa

505004

Mediclinic City Hospital ( Site 2005), Dubai

630048

Children's City Clinical Hospital #1 ( Site 1604), Novosibirsk

634050

Siberian State Medical University ( Site 1602), Tomsk

3350121

Armon M.C ( Site 0803), Haifa

3525408

Rambam Medical Center ( Site 0801), Haifa

5265601

The Edmond and Lily Safra Children s Hospital ( Site 0804), Ramat Gan

8410101

Soroka University Medical Center ( Site 0802), Beersheba

9124001

Hadassah Mount Scopus ( Site 0800), Jerusalem

35233-1711

The University of Alabama at Birmingham ( Site 2207), Birmingham

N6A 5W9

London Health Sciences Centre ( Site 0002), London

H1T 2M4

Hopital Maisonneuve-Rosemont CIUSSS de l Est de L Ile de Montreal ( Site 0001), Montreal

080020

Centro De Diabetes Cardiovascular IPS Ltda ( Site 0101), Barranquilla

01009

Endopedia ( Site 0503), Guatemala City

01014

Private Practice - Dr. Flor de Maria Ranchos Monterroso ( Site 0502), Guatemala City

00165

IRCCS Ospedale Pediatrico Bambino Gesu ( Site 0903), Roma

06760

CAIMED Investigación en Salud S.A de C.V ( Site 1008), Mexico City

85-046

IN VIVO ( Site 1501), Bydgoszcz

33-122

Poradnia Chorob Metabolicznych. Centrum Zdrowia Tuchow ( Site 1500), Wierzchosławice

02-117

Instytut Diabetologii Sp z o o ( Site 1512), Warsaw

40-156

Clinical Medical Research Sp. z o.o. ( Site 1511), Katowice

01330

Cukurova Uni. Tip Fakultesi ( Site 2403), Adana

06800

Ankara Bilkent Şehir Hastanesi-Çocuk Hastanesi, Çocuk Endokrinoloji ( Site 2407), Ankara

01021

Ukr Center of Endocrine Surgery and Transplatation MOH Ukraine ( Site 1903), Kyiv

03039

Medical Center Verum ( Site 1913), Kyiv

04114

Institute of Endocrinology and Metabolism n.a. Komissarenko ( Site 1905), Kyiv

E1 1FR

Royal London Hospital (Whitechapel) ( Site 2100), London

SW10 9NH

Chelsea and Westminster Hospital ( Site 2103), London

TW7 6AF

West Middlesex University Hospital ( Site 2104), London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04029480 - Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059) | Biotech Hunter | Biotech Hunter