Validating Reward-related Biomarkers (RTOC)

CompletedOBSERVATIONAL
Enrollment

160

Participants

Timeline

Start Date

September 16, 2019

Primary Completion Date

February 1, 2021

Study Completion Date

February 1, 2021

Conditions
SchizophreniaDepressionMotivationAnhedonia, PhysicalAnhedonia, SocialNegative Symptoms With Primary Psychotic Disorder
Interventions
BEHAVIORAL

Self-rating Questionnaires

"* Snaith-Hamilton Pleasure Scale (SHAPS; Snaith et al. 1995)~* Quick Inventory of Depressive Symptomatology (QIDS; 16 items)~* Behavioral avoidance/inhibition Scales (BIS/BAS)"

BEHAVIORAL

Measures of Reward processing/reinforcement learning

"* Grip Strength Effort Task (Reddy et al. 2015; in combination with EEG)~* Doors (Gambling) task (Foti and Hajcak 2009; in combination with EEG)~* Reinforcement Learning/Working Memory task (Collins et al. 2017; no EEG)"

BEHAVIORAL

Additional Schizophrenia-specific Questionnaires and Interviews

"* Positive and Negative Syndrome Scale (PANSS: Kay et al. 1987)~* Brief Negative Symptom Scale (BNSS; Kirkpatrick et al. 2011)"

Trial Locations (4)

Unknown

University Hospital Frankfurt, Department of Psychiatry, Psychosomatic Medicine and Psychotherap, Frankfurt

Aristotle University of Thessaloniki, School of Medicine, Department of Clinical Pharmacology, Thessaloniki

Maastricht University, Maastricht

Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, Barcelona, Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

P1vital Products LTD.

UNKNOWN

collaborator

Biotrial

INDUSTRY

collaborator

University Hospital Frankfurt, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy

UNKNOWN

collaborator

The Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, Barcelona

UNKNOWN

collaborator

Aristotle University Of Thessaloniki

OTHER

collaborator

Maastricht University, School for Mental Health and Neuroscience

UNKNOWN

lead

Maastricht University

OTHER

NCT04024371 - Validating Reward-related Biomarkers (RTOC) | Biotech Hunter | Biotech Hunter