Task Shifting to Treat Depression and HIV Medication Nonadherence in Low Resource Settings

NAActive, not recruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

July 12, 2019

Primary Completion Date

March 31, 2025

Study Completion Date

March 31, 2025

Conditions
HIV InfectionsDepression
Interventions
BEHAVIORAL

Stepped care for nonadherence and depression

"* Problem Solving for Depression and Adherence: A 6-session adherence and depression intervention based on a culturally adapted LifeSteps and Problem Solving Therapy for Depression.~* Stepped Care Assessment for Antidepressant Treatment: If a participant's depression score remains above threshold in Session 6, the study interventionist will refer the participant to a Research Mental Health Nurse for a psychopharmacological assessment to prescribe an antidepressant to augment Problem Solving for Depression and Adherence."

OTHER

Enhanced Usual Care

Enhanced Usual Care: A combination of 1) clinic-provided adherence counseling, 2) access to providers trained in the World Health Organization Mental Health Gap Intervention Guide (mhGAP), 3) a letter to the participant's medical provider detailing the depression diagnosis, 4) access to the treatment components of the TENDAI intervention at no cost, after the participant has completed their 12-month follow-up assessment.

Trial Locations (1)

Unknown

Marondera Provincial Hospital, Marondera

All Listed Sponsors
collaborator

Massachusetts General Hospital

OTHER

collaborator

University of Zimbabwe College of Health Sciences

UNKNOWN

collaborator

National Institute of Mental Health (NIMH)

NIH

lead

King's College London

OTHER

NCT04018391 - Task Shifting to Treat Depression and HIV Medication Nonadherence in Low Resource Settings | Biotech Hunter | Biotech Hunter