A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes

PHASE3CompletedINTERVENTIONAL
Enrollment

1,441

Participants

Timeline

Start Date

July 29, 2019

Primary Completion Date

October 27, 2021

Study Completion Date

October 27, 2021

Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG

Oral semaglutide

Oral semaglutide to be taken every morning in a fasting state, to be followed by sitagliptin placebo after 30 minutes. Only then participants can have their first meal of the day and their pre-study metformin tablets

DRUG

Sitagliptin

Sitagliptin to be taken every morning, 30 minutes after taking the oral semaglutide placebo tablet. Then participants can have their first meal of the day and their pre-study metformin tablets

DRUG

Placebo (oral semaglutide)

Placebo tablet to be taken first thing in the morning

DRUG

Placebo (sitagliptin)

Placebo tablet to be taken 30 minutes after oral semaglutide

Trial Locations (93)

100

National Taiwan University Hospital, Taipei

112

Taipei Veterans General Hospital, Taipei

114

Tri-Service General Hospital, Taipei

333

Chang Gung Medical Foundation - Linko Branch, Taoyuan

1449

Union Hospital, Alberton

1619

Clinresco Centres (Pty) Ltd, Kempton Park

1812

Dr R Dulabh, Johannesburg

2001

Newtown Clinical Research, Johannesburg

2193

WITS Clinical Research, Johannesburg

7580

Cape Town Medical Research Centre, Kuilsriver

7646

Paarl Reserch Centre, Paarl

11000

Clinical Hospital Centre Dragisa Misovic, Belgrade

Endocrinology, Diabetes and Metabolism Diseases Clinic, Belgrade

11080

Clinical Hospital Centre Zemun, Belgrade

13682

SC Nutrilife SRL, Bucharest

16000

Maison des diabétiques El Harrach, Algiers

16003

Department of internal medicine hospital (CHU) of BIRTRARIA, Algiers

46001

Interna a diabetologie MUDr. Vodickova, Liberec

63900

Nemocnice milosrdnych bratri, Brno

100044

Peking University People's Hospital, Beijing

100144

Peking University Shougang Hospital, Beijing

101200

Beijing Pinggu Hospital, Beijing

130021

Jilin Province People's Hospital, Changchun

130033

China-Japan Union Hospital of Jilin University, Changchun

130041

The Second Hospital of Jilin University, Changchun

200040

Shanghai Huashan Hospital, Affiliated to Fudan University, Shanghai

200065

Tongji Hospital of Tongji university, Shanghai

200072

Shanghai Tenth People's Hsopital, Tongji University, Shanghai

200120

Dongfang Hospital Affiliated to Shanghai Tongji University, Shanghai

200240

The Fifth People's Hospital of Shanghai, Shanghai

200336

Tongren Hospital Shanghai Jiao Tong Univ. School of Medicine, Shanghai

201200

Shanghai Pudong New Area People's Hospital, Pudong New District

210011

The Second Affiliated Hospital of Nanjing Medical University, Nanjing

211106

Nanjing Jiangning Hospital, Nanjing

211166

Sir Run Run Hospital Nanjing Medical University, Nanjing

212001

The Affiliated Hospital of Jiangsu University, Zhenjiang

213003

Changzhou No.2 People's Hospital, Yanghu Branch, Changzhou

The First People's Hospital of Changzhou, Changzhou

214023

Wuxi People's Hospital, Wuxi

215004

The Second Affiliated Hospital of Soochow University, Suzhou

215006

The First Affiliated Hospital of Soochow University, Suzhou

221002

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

230001

Anhui Provincial Hospital, Hefei

230061

The First Affiliated Hospital of Anhui Medical University, Hefei

250013

Jinan Central Hospital Affiliated to Shandong University, Jinan

261041

Weifang People's Hospital, Weifang

266003

The Affiliated Hospital of Qingdao Medical College, Qingdao

300052

General Hospital of Tianjin Medical University, Tianjin

300211

The Second Hospital of Tianjin Medical University, Tianjin

300456

SC Centru Medical Dr. Negrisanu SRL, Timișoara

310009

The 2nd Affi Hosp of Zhejiang Univer School of Medicine, Hangzhou

337055

Pingxiang People's Hospital, Pingxiang

350025

900th Hospital of Joint Logistics Support Force, Fuzhou

362000

The Second Affiliated Hospital of Fujian Medical University, Quanzhou

400010

Second Affliated Hospital of Chongqing Medical University, Chongqing

410013

The Third Xiangya Hospital of Central South University, Changsha

410018

Changsha Central Hospital, Changsha

410025

SC Grand Med SRL, Oradea

410151

S.C. Endodigest S.R.L., Oradea

410169

Clinical County Emergency Hosp, Oradea

412007

Zhuzhou Central Hospital, Zhuzhou

421001

The First Affiliated Hospital Of University Of South China, Hengyang

423000

Chenzhou No.1 People's Hospital, Chenzhou

430034

Wuhan Puai Hosptial, Wuhan

442008

Taihe Hospital, Shiyan

450004

Zhengzhou First People's Hospital, Zhengzhou

471003

The First Affiliated Hospital of Henan university of Science, Luoyang

475000

Huaihe Hospital of Henan University, Kaifeng

510120

Sun Yat-sen Memorial Hospital, Sun Yat-sen Universtiy, Guangzhou

511400

Guangzhou Panyu Central Hospital, Guangzhou

515065

The 2nd Affiliated Hospital of Shantou Uni Medical College, Shantou

516001

Huizhou Central People's Hospital, Huizhou

528399

Shunde Hospital of Southern Medical University, Foshan

650032

First Affiated Hospital of Kunming Medical University, Kunming

The First People's Hospital of Yunnan Province, Kunming

650101

The Second Affiliated Hospital of Kunming Medical University, Kunming

710004

The second Affiliated Hospital of Xi'an Jiaotong University, Xi'an

750004

General Hospital of Ningxia Medical University, Yinchuan

810007

Qinghai Provincial People's Hospital, Xining

900591

Clinic of Diabetes Constanta, Constanța

90430-001

Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda., Porto Alegre

01228-000

CPQuali Pesquisa Clínica Ltda, São Paulo

01228-200

CPCLIN - Centro de Pesquisas Clínicas, São Paulo

061000

Cangzhou People's Hospital, Cangzhou

053000

Harrison International Peace Hospital, Hengshui

050000

The Second Hospital of Hebei Medical University, Shijiazhuang

537 01

DIAMIN, Chrudim

130 00

CCR Prague, Prague

140 00

MUDr. Michala Pelikanova, Prague

Unknown

Prince of Wales Hospital, Shatin, New Territories

0083

GCT, Arcadia

0152

Setshaba Research Centre, Soshanguve

0250

Armansis Medical Centre, Brits

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY