Therapeutic Efficacy of Intravenous Lidocaine Infusion Compared With Epidural Analgesia for Postoperative Pain Control in Adult Patients Undergoing Major Abdominal Surgery: Non-Inferiority Clinical Trial

PHASE4CompletedINTERVENTIONAL
Enrollment

210

Participants

Timeline

Start Date

March 1, 2020

Primary Completion Date

September 5, 2022

Study Completion Date

September 5, 2022

Conditions
Pain, PostoperativeOpioid Use
Interventions
PROCEDURE

Epidural Analgesia

"The epidural infusion will be as follows:~* Isobaric Bupivacaine 0.5% 40 cc~* Morphine 4 mg (1 ampoule up to 10 cc and 4 cc of the mixture will be applied)~* Saline solution 0.9% 156 cc.~* Total Volume: 200 cc.~This mixture will be prepared by a nurse outside the research group outside the operating room once indicated.~The infusion will be scheduled at 7 cc / hour per continuous infusion set and will be connected to the epidural catheter after its placement."

DRUG

Lidocaine Infusion

2% Lidocaine IV without epinephrine: 1 mg/kg/ hour for up to 24 hours, started immediately after anesthetic induction.

Trial Locations (1)

Unknown

Antioquias Univervesity Health Institution, Medellín

All Listed Sponsors
collaborator

IPS Universitaria-Universidad de Antioquia

UNKNOWN

lead

Universidad de Antioquia

OTHER

NCT04017013 - Therapeutic Efficacy of Intravenous Lidocaine Infusion Compared With Epidural Analgesia for Postoperative Pain Control in Adult Patients Undergoing Major Abdominal Surgery: Non-Inferiority Clinical Trial | Biotech Hunter | Biotech Hunter