Comparative Study Between Single Versus Dual Trigger for Poor Responders in GnRH-antagonist ICSI Cycles

PHASE4CompletedINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

July 20, 2016

Primary Completion Date

June 2, 2019

Study Completion Date

July 1, 2019

Conditions
Assisted Reproduction
Interventions
DRUG

combined oral contaraceptive pills

1 tablet daily between days 5 and 25 of the cycle before stimulation

DRUG

recombinant FSH

300 U from the 2nd day of the cycle then the dose was adjusted according to the ovarian response evaluated by transvaginal ultrasound and serum E2

DRUG

Urinaru gonadotropin

150 U from the 2nd day of the cycle then the dose was adjusted according to the ovarian response evaluated by transvaginal ultrasound and serum E2

DRUG

GnRH antagonist

0.25 subcutaneously daily from the day in which the leading follicles reached 12 mm till the day of triggering

DRUG

Human chorionic gonadotropin

10,000 IU intramuscular when at least 3 follicles larger than 14 mm and at least one of them reached a mean diameter of 17 mm or more

DRUG

GnRH agonist

0.2 mg subcutaneously when at least 3 follicles larger than 14 mm and at least one of them reached a mean diameter of 17 mm or more

PROCEDURE

Ovum pick up

34 hours after triggering under the guidance of transvaginal ultrasound

PROCEDURE

Embryo transfer

Transabdominal ultrasound guided embryo transfer was done 3 days after oocyte retrieval using Labotect semirigid catheter

DRUG

natural Progesterone

400 mg twice daily per vagina

Trial Locations (1)

12151

Kasr Alainy medical school, Cairo

All Listed Sponsors
lead

Cairo University

OTHER

NCT04008966 - Comparative Study Between Single Versus Dual Trigger for Poor Responders in GnRH-antagonist ICSI Cycles | Biotech Hunter | Biotech Hunter