Combination of Toripalimab and Chemoradiotherapy in Esophageal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

June 25, 2019

Primary Completion Date

December 31, 2020

Study Completion Date

July 31, 2022

Conditions
Unresectable Esophageal Cancer
Interventions
DRUG

Toripalimab

Patients received toripalimab 240 mg on days 1 and 22 during radiotherapy followed by a maintenance phase of toripalimab IV 240 mg every 3 weeks for up to 1 year.

DRUG

Paclitaxel/Cisplatin

Patients received 5 cycles of paclitaxel/cisplatin (paclitaxel 50mg/m2 and cisplatin 25 mg/m2) on days 1, 8, 15, 22, 29 during radiotherapy.

RADIATION

Intensity-modulated radiotherapy

All patients received external-beam radiation using intensity-modulated radiotherapy. The prescribed dose is 50.4 Gy in 28 fractions over 5-6 weeks.

Trial Locations (1)

510060

Sun Yat-sen University Cancer Center, Guanzhou

All Listed Sponsors
lead

Mian XI

OTHER

NCT04005170 - Combination of Toripalimab and Chemoradiotherapy in Esophageal Cancer | Biotech Hunter | Biotech Hunter