510
Participants
Start Date
August 20, 2019
Primary Completion Date
March 31, 2027
Study Completion Date
December 31, 2027
zanubrutinib
Administered as two 80 mg capsules by mouth twice a day
bendamustine
Administered intravenously at a dose of 90 mg/m2/day on Days 1 and 2 of Cycles 1 to 6
rituximab
Administered intravenously at a dose of 375 mg/m2 on Day 1 of Cycles 1 to 6
Tri Service General Hospital, Taipei
National Cheng Kung University Hospital, Tainan City
Chi Mei Hospital Liouying, Tainan City
Medical University Vienna Oncology, Vienna
Universitair Ziekenhuis Brussel, Brussels
Saint Vincents Hospital Sydney, Darlinghurst
Concord Repatriation General Hospital, Concord
Gosford Hospital, Gosford
Calvary Mater Newcastle, Waratah
The Tweed Valley Hospital, Cudgen
Canberra Hospital, Garran
Uz Antwerpen, Edegem
National Cancer Institute, Kiev
St Vincents Hospital Melbourne, Fitzroy
Tauranga Hospital, Tauranga
Monash Health, Clayton
Peninsula Private Hospital, Frankston
Barwon Health the Geelong Hospital, Geelong
Centre Hospitalier Universitaire (Chu) de Liege Site Du Sart Tilman, Liège
Ordensklinikum Linz Gmbh Elisabethinen, Linz
Icon Cancer Foundation, South Brisbane
Sunshine Coast Hospital and Health Service, Birtinya
Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg, Salzburg
Flinders Medical Centre, Bedford PK
Centre Hospitalier Universitaire Universite Catholique de Louvain Site Godinne, Yvoir
Royal Perth Hospital, Perth
Gazi University, Ankara
Royal Hobart Hospital, Hobart
Az Sint Jan Brugge, Bruges
Christchurch Hospital (Canterbury Health Laboratories), Christchurch
Az Groeninge Campus Loofstraat, Kortrijk
Icahn School of Medicine At Mount Sinai, New York
Ao Citta Della Salute E Della Scienza Di Torino Presidio O, Torino
Clinical Research Alliance, Inc, Westbury
Institut Paoli Calmettes, Marseille
Azienda Ospedaliera Nazionale Ssantonio E Biagio E Cesare Arrigo, Alessandria
West Penn Hospital, Pittsburgh
Azienda Ospedaliera Universitaria San Martino, Genova
Ico Girona, Girona
Cherkasy Regional Oncology Dispensary, Cherkasy
Niguarda Cancer Center Division of Hematology, Milan
Tr Trakya University Health Research and Application Center (Hospital), Edirne
Hospital Universitario Gregorio Maranon, Madrid
Md Anderson Cancer Center Madrid Spain, Madrid
Start Madrid Fundacion Jimenez Diaz, Madrid
Hospital Universitario La Paz, Madrid
Aou Maggiore Della Carita, Novara
Ch Cornouaille, Quimper
Hospital Regional Universitario de Malaga, Málaga
Chru de Brest Hospital Morvan, Brest
Iuc Toulouse Oncopole, Toulouse
Mersin Universitesi Tip Fakultesi Hastanesi, Mersin
Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux
Vkv American Hospital, Istanbul
University of Verona, Verona
Chu Grenoble Alpes, Grenoble
Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna
Hospital Universitario Virgen Del Rocio, Seville
Azienda Unita Sanitaria Locale Irccs, Reggio Emilia
Petrus Krankenhaus Wuppertal, Wuppertal
Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes
University of Michigan Health System, Ann Arbor
Unita Di Ematologia, Dipartimento Di Ematologia Ed Oncologia, Ravenna
Municipal Non Profit Enterprise City Clinical Hospital, Dnipro
Uniklinik Koln (Aor), Cologne
Aou Senese Policlinico Santa Maria Alle Scotte, Siena
Aou Pisana, Stabilimento Di Santa Chiara, Pisa
Hopital Claude Huriez Chu Lille, Lille
Rush University Medical Center, Chicago
Universitatsklinikum Heidelberg, Heidelberg
Chu Hopital Lyon Sud, PierreBenite
Centre Hospitalier Le Mans, Le Mans
Institut Curie, Paris
Necker University Hospital, Paris
Si Institute of Blood Pathology and Transfusion Medicine Nams of Ukraine, Hematology Department, Lviv
Joe Arrington Cancer Research and Treatment Center, Lubbock
Dept of Medicine Iii, University Hospitallmu, Munich
Centre Hospitalier Universitaire de Poitier Hopital de La Miletrie Hopital Jean Bernard, Poitiers
Universitaetsklinikum Ulm, Innere Medizin Iii, Ulm
Comprehensive Cancer Centers of Nevada, Las Vegas
Aoor Villa Sofia Cervello, Palermo
Chao Family Comprehensive Cancer Center, Orange
Providence Portland Medical Center, Portland
Seattle Cancer Care Alliance, Seattle
Peking University Peoples Hospital, Beijing
Beijing Friendship Hospital, Capital Medical University, Beijing
Shengjing Hospital of China Medical University, Shenyang
Clinical Hospital, Sp Botkin, Moscow
Jilin Cancer Hospital, Changchun
The First Hospital of Jilin University, Changchun
Gbuz Mmcc Kommunarka Dzm, Moscow
Harbin Medical University Cancer Hospital, Harbin
Fgu Russian Scientific Research Institute of Hematology and Transfusiology, Saint Petersburg
Leningrad Regional Clinic and Hospital, Saint Petersburg
Fudan University Shanghai Cancer Center, Shanghai
Shanghai East Hospital, Shanghai
Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School, Nanjing
Jiangsu Province Hospital, Nanjing
The Affiliated Hospital of Xuzhou Medical University, Xuzhou
Institute of Hematology and Hospital of Blood Disease, Tianjin
Tianjin Medical University Cancer Institute and Hospital, Tianjin
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
Hwa Mei Hospital, University of Chinese Academy of Sciences (Ningbo No Hospital), Ningbo
The First Affiliated Hospital of Nanchang University Branch Donghu, Nanchang
Fujian Medical University Union Hospital, Fuzhou
Quanzhou First Affliated Hospital of Fujian Medical University, Quanzhou
Hunan Cancer Hospital, Changsha
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan
Henan Cancer Hospital, Zhengzhou
Sun Yat Sen University Cancer Center, Guangzhou
Guangdong Provincial Peoples Hospital, Guangzhou
Nanfang Hospital of Southern Medical University, Guangzhou
West China Hospital, Sichuan University, Chengdu
Institutul Regional de Oncologie Iasi, Iași
Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi
Beth Israel Deaconess Medical Center (Bidmc), Boston
The University of Texas Md Anderson Cancer Center, Houston
The Ottawa Hospital, Ottawa
Ciusss de Lestrie Chus, Sherbrooke
Chu Dijon, Dijon
Cork University Hospital, Cork
Mater Misericordiae University Hospital, Dublin
St Jamess Hospital, Dublin
University Hospital Galway, Galway
University Hospital Limerick, Limerick
University Hospital Waterford, Waterford
Universita Degli Studi La Sapienza, Roma
National Hospital Organization Nagoya Medical Center, Nagoya
Toyohashi Municipal Hospital, Toyohashi
Chiba Cancer Center, Chiba
Kurume University Hospital, Kurume
Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima
Kanagawa Cancer Center, Yokohama
National Hospital Organization Kumamoto Medical Center, Kumamoto
Tohoku University Hospital, Sendai
Kurashiki Central Hospital, Kurashikishi
Osaka Red Cross Hospital, Osakashi
National Cancer Center Hospital, Chuoku
University Hospital, Kyoto Prefectural Univ of Medicine, Kyoto
National Hospital Organization Okayama Medical Center, Okayama
Osaka Metropolitan University Hospital, Osaka
Tokyo Medical and Dental University Hospital, Tokyo
Yokohama Municipal Citizens Hospital, Yokohama
Admiraal de Ruijter Ziekenhuis, Goes
University of Medical Center Groningen (Umcg), Groningen
St Antonius Ziekenhuis, Randd Interne Geneeskunde (F), Nieuwegein
Albert Schweitzer Ziekenhuis, Nijmegen
Erasmus Mc, Rotterdam
Hagaziekenhuis, The Hague
Szpital Uniwersytecki Nr Im Dr Jana Biziela, Bydgoszcz
Silesian Healthy Blood Clinic, Chorzów
Uniwersyteckie Centrum Kliniczne, Gdansk
Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii, Gdask
Szpitale Pomorskie Spolka Z Ograniczona Odpowiedzialnoscia, Gdynia
Pratia McM Krakow, Krakow
Wojewodzki Szpital Specjalistyczny W Legnicy, Legnica
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz
Centrum Onkologii Ziemi Lubelskiej, Lublin
Instytut Hematologii I Transfuzjologii W Warszawie, Warsaw
Specjalistyczny Szpital Im Dr Alfreda Sokolowskiego, Wałbrzych
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu, Wroclaw
Instituto Portugues Oncologia de Lisboa Francisco Gentil, Epe, Lisbon
Chuln Hospital de Santa Maria, Lisbon
Centro Hospitalar Universitario Porto, Porto
Instituto Portugues de Oncologia Do Porto Francisco Gentil, Epe, Porto
Institutul Clinic Fundeni, Bucharest
Hospital Universitario Vall Dhebron, Barcelona
Institut Catala Doncologia, Barcelona
Ico Hug Trias I Pujol, Barcelona
Dr Abdurrahman Yurtaslan Oncology Teaching and Research Hospital, Ankara
Hematoloji Ve Hematolik Onkoloji Tani Ve Tedavi Merezi, Ankara
Aneurin Bevan University Health Board, Abergavenny
Birmingham Heartlands Hospital, Birmingham
Russells Hall Hopsital, Dudley
Royal Marsden Nhs Foundation Royal Marsden Hospital, Sutton
Lead Sponsor
BeiGene
INDUSTRY