A Cross-sectional Study to Measure Cough in Severe Asthma

NACompletedINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

October 4, 2017

Primary Completion Date

December 30, 2019

Study Completion Date

December 30, 2019

Conditions
AsthmaCough
Interventions
DRUG

Citric acid

Citric Acid cough challenge to be administered to assess the cough reflex sensitivity in patients

DEVICE

Leicester Cough monitor

Ambulatory cough monitor to assess cough frequency over a 24 hour period

OTHER

fractional exhaled nitric oxide testing (FeNO)

Measurement of exhaled nitric oxide to give an indication of airway inflammation

OTHER

Patient reported outcome measures

A number a patient reported outcome measures will be administered including: Asthma control questionnaire (ACQ-5), mini Asthma Quality of Life Questionnaire (mini AQLQ), Leicester Cough Questionnaire (LCQ), Cough Quality of Life Questionnaire (CQLQ), Cough Hypersensitivity Questionnaire (CHQ) and visual analogue scales for severity og cough (VASc) and Urge to Cough (VASu)

Trial Locations (1)

BT7 1NN

Queen's University Belfast, Belfast

All Listed Sponsors
collaborator

King's College London

OTHER

lead

Queen's University, Belfast

OTHER

NCT03999203 - A Cross-sectional Study to Measure Cough in Severe Asthma | Biotech Hunter | Biotech Hunter