Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?

NANot yet recruitingINTERVENTIONAL
Enrollment

81

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

February 1, 2028

Study Completion Date

August 1, 2028

Conditions
LymphedemaKetogenic DietingKetone Ester Supplement
Interventions
DIETARY_SUPPLEMENT

Ketogenic diet

Ketocal, a nutritionally complete ready-to-drink liquid, is foreseen to ensure adequate amounts of vitamins and minerals will be used. After 24 weeks a Modified Atkins diet will be started.

DIETARY_SUPPLEMENT

Isocaloric diet

Patients will follow an isocaloric diet

DIETARY_SUPPLEMENT

Ketone ester supplementation

25g of a ketone monoester, ingested 3 times a day for a period of 12 weeks. Ingestion is separated from a meal and interspersed by at least 4 hours to ensure maximal available ketone bodies circulating in the blood.

Trial Locations (1)

3000

UZ Leuven, Leuven

All Listed Sponsors
lead

Universitaire Ziekenhuizen KU Leuven

OTHER

NCT03991897 - Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients? | Biotech Hunter | Biotech Hunter