Lack of Decision-making in Patients With Alzheimer's Disease : Functions Involved and the Daily Consequences

NARecruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

September 27, 2019

Primary Completion Date

October 31, 2025

Study Completion Date

October 31, 2025

Conditions
Alzheimer Disease
Interventions
DIAGNOSTIC_TEST

cognitive assessment

"* MMSE : Mini-Mental State Examination~* 5 words of Dubois~* Direct Assessment of Functional Status~* Trail Making Test~* BREF : Fast Front End Efficiency Battery~* short battery of praxies~* Quality of Life in Alzheimer's Disease"

OTHER

Inhibition evaluation

"* Stroop Victoria : This test consists of 3 sheets of 24 items, organized in 6 lines of 4 (points, neutral words or names of colours), from which the subject must identify the ink of the stimuli as quickly and precisely as possible.~* Stop Signal task on the computer to give a response to the presentation of a target stimulus (Go signal) (e.g. pressing a button when a red circle appears on the screen, but doing nothing when a blue triangle appears), and prevent this response when the stimulus is followed or preceded by a beep (stop signal) (e.g. the appearance of a red circle is immediately preceded or followed by a beep, the subject should not press the button)."

OTHER

Assessment of mental flexibility

"* a letter-number pair task. The subject sees 4 blocks of 48 letter-number pairs appear successively on a screen. When the pair appears at the top, the subject must make a parity judgment but when the pair appears at the bottom, the subject must make a consonant / vowel judgment.~* a category change task, which consists in classifying a word according to one category or another according to a visual clue that appears. The task consists of 4 blocks of 48 stimuli."

OTHER

Evaluation of the update

"* an update span task for which letters appear on a screen sequentially, and subjects must memorize the last three, without knowing the length of the list. The task will consist of 3 tests of training and then 20 tests. After three errors consecutive, the task ends.~* an n-back task that consists of a sequential presentation of letters, during which the subject must indicate when the stimulus. The task consists of 3 levels, with n = 1, n= 2 or n = 3. For level 1 (with n = 1), the subject must press a button when the same letter appears twice in a row on the screen. This task consists of 75 letters."

OTHER

working memory

"* the empan baba task, which mainly involves maintaining information, and which consists in retaining a series of letters, appearing sequentially on a screen, and whose latency time between two word presentations is required for a secondary task: the repetition of baba syllables.~* the task of reading operations which consists in recalling operations series of letters whose presentation is interspersed with the reading aloud of simple operations and of their results.~* the ongoing operational task of recalling a list of letters, the presentation of which is interspersed with operations that are simple to read aloud and to to solve head-on."

OTHER

episodic memory

\- A recognition task with a Remember/Know paradigm

Trial Locations (4)

42055

RECRUITING

CHU de Saint Etienne, Saint-Etienne

69100

NOT_YET_RECRUITING

CMRR - Hôpital Charpennes, Villeurbanne

69676

RECRUITING

Laboratoire d'Etude des Mécanismes Cognitifs, Bron

75010

NOT_YET_RECRUITING

Hôpital Lariboisière- Fernand Widal, Paris

All Listed Sponsors
lead

Centre Hospitalier Universitaire de Saint Etienne

OTHER