84
Participants
Start Date
December 23, 2020
Primary Completion Date
May 22, 2022
Study Completion Date
December 10, 2023
Manganese Chloride
Administered by inhalation at 0.4mg/kg twice per week in the first 3-week cycle, and then inhaled 0.4mg/kg twice in the first week of each 3-week cycle thereafter
nab-paclitaxel
Administered intravenously, 180-220mg/m2 on day 2 in a 3-week cycle (day 1 without Manganese priming)
Platinum chemotherapy
Administered intravenously, Cisplatin (60-80mg/m2) or Carboplatin (area under the curve \[AUC\] 4-6 mg/mL per min) on day 2 in a 3-week cycle (day 1 without Manganese priming)
Sintilimab
Administered intravenously, 200mg on day 3 in a 3-week cycle (day 2 without Manganese priming)
Biotherapeutic Department of Chinese PLA General Hospital, Beijing
Chinese PLA General Hospital
OTHER